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Cross-linked Hyaluronic Acid in Knee Osteoarthritis

Key facts

Who runs it
Istanbul Medipol University Hospital
Where
Türkiye1 site in 1 countryChoose a country to see its sites
Trial code
Status
Completed
People taking part
88 people enrolled
Started
2 Jan 2021
Ended
31 May 2025
Type of study
Observational
Treatments tested
  • Straight-bonded hyaluronic acid
  • cross-linked hyaluronic acid
Record updated
27 February 2026

Who can take part

Age
50 years to 70 years
Sex
Women and men
Healthy volunteers
Can take part

This trial has no sites in United States.

It has sites in one country. Choose a country to see its sites.

About the trial

What the trial wants to find out

Knee Osteoarthritis (Knee OA) leads to pain and loss of function, especially in recreational athletes. While hyaluronic acid (HA) injections are a common part of conservative treatment, comparative data on the efficacy of straight-chain (ST-HA) versus cross-linked (CL-HA) formulations remain limited. Therefore, the aim of this study was to compare the 6-month efficacy of a single dose of CL-HA versus two doses of ST-HA regarding pain, stiffness, and joint function in recreational athletes aged 50-70 with Kellgren-Lawrence grade 2-3 Knee OA refractory to pharmacological treatment.

Treatments tested

  • Straight-bonded hyaluronic acid
  • cross-linked hyaluronic acid

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
Clinical Superiority of Cross-linked Hyaluronic Acid in Knee Osteoarthritis: Sustained Efficacy on Pain and Function
Record updated
27 February 2026