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Ongericimab Injection Reducing Recurrence of Ischemic Stroke

Key facts

Where
Anshun, Baise City, Baoding, Baotou, Bayan Nur, Beijing, Benxi, Binzhou, Changchun, Changde, Changsha, Changzhi, Chenzhou, Chifeng, Chongqing, Dalian, Dandong, Daqing, Dezhou, Dingxi, Dongying, Fushun, Fuyang, Haikou, Handan, Harbin, Hebi, Heihe, Hejian, Hengshui, Heze, Hohhot, Huai'an, Huizhou, Huludao, Huzhou, Jiamusi, Jiaozuo, Jiaxing, Jingdezhen, Jining, Jiujiang, Jiuquan, Jixi, Jiyuan, Kaili, Lanzhou, Liaocheng, Linfen, Lishui, Liuzhou, Loudi, Luoyang, Meihekou, Meishan, Nanyang, Ningde, Nujiang, Pingdingshan, Pu'er, Puyang, Qingdao, Qinhuangdao, Qiqihar, Sanmenxia, Shanghai, Shangqiu, Shangrao, Shaoguan, Shaoxing, Shenmu, Shenyang, Shijiazhuang, Shizuishan, Shuangyashan, Shuozhou, Siping, Suining, Suqian, Tai’an, Taiyuan, Tangshan, Tianshui, Tieling, Tonghua, Tongliao, Tongren, Ürümqi, Weifang, Weihai, Wenzhou, Wuhan, Wuhu, Xi'an, Xianning, Xingtai, Xining, Xinxiang, Xinyang, Xuchang, Yakeshi, Yan’an, Yangquan, Yantai, Yibin, Yongzhou, Zhalantun, Zhangjiakou, Zhanjiang, Zhengzhou, Zhoukou, and Zhumadian, ChinaSee the 197 sites
Phase
Phase 3

Where in China

  • Puding County People's HospitalAnshun, ChinaNo longer taking part
  • Baise City People's HospitalBaise City, ChinaNo longer taking part
  • Affiliated Hospital of Hebei UniversityBaoding, ChinaNo longer taking part
  • Hebei Tang County People's HospitalBaoding, ChinaNo longer taking part
  • The No.2 Hospital Of BaodingBaoding, ChinaNo longer taking part
  • Baotou City Central HospitalBaotou, ChinaNo longer taking part
  • Sinopharm North HospitalBaotou, ChinaNo longer taking part
  • Bayannur HospitalBayan Nur, ChinaNo longer taking part
  • WuYuan County People's HospitalBayan Nur, ChinaNo longer taking part
  • Beijing Tiantan Hospital,Capital Medical UniversityBeijing, ChinaNo longer taking part
  • The First Hospital of Fangshan District, BeijingBeijing, ChinaNo longer taking part
  • Benxi Central HospitalBenxi, ChinaNo longer taking part
  • General Hospital of Benxi IronBenxi, ChinaNo longer taking part
  • Binzhou Medical University HospitalBinzhou, ChinaNo longer taking part
  • Yangxin County People's HospitalBinzhou, ChinaNo longer taking part
  • China-Japan Union Hospital of JiLin UniversityChangchun, ChinaNo longer taking part
  • Taoyuan People'S HospitalChangde, ChinaNo longer taking part
  • Liuyang Jili HospitalChangsha, ChinaNo longer taking part
  • Changzhi People's HospitalChangzhi, ChinaNo longer taking part
  • Chenzhou 3rd People's HospitalChenzhou, ChinaNo longer taking part
  • Chenzhou No.1 People's HospitalChenzhou, ChinaNo longer taking part
  • Affiliated Hospital of Chifeng UniversityChifeng, ChinaNo longer taking part
  • Chifeng City Center Hospital Ningcheng CountyChifeng, ChinaNo longer taking part
  • Chifeng Hospital of Traditional Chinese and Mongolian MedicineChifeng, ChinaNo longer taking part
  • Ningcheng County Hospital of Traditional Chinese and Mongolian MedicineChifeng, ChinaNo longer taking part
  • Chongqing Sanbo Changan HospitalChongqing, ChinaNo longer taking part
  • The Fifth People's Hospital of ChongqingChongqing, ChinaNo longer taking part
  • The First Affiliated Hospital of Chongqing Medical and Pharmaceutical CollegeChongqing, ChinaNo longer taking part
  • Central Hospital of Dalian University of Technology (Dalian Municipal Central Hospital)Dalian, ChinaNo longer taking part
  • Dalian Jinzhou District First People's HospitalDalian, ChinaNo longer taking part
  • Dalian Lvshunkou District Traditional Chinese Medicine HospitalDalian, ChinaNo longer taking part
  • Dalian University Affiliated Xinhua HospitalDalian, ChinaNo longer taking part
  • The First Affiliated Hospital of Dalian Medical UniversityDalian, ChinaNo longer taking part
  • Wafangdian Third Hospital Co., Ltd.Dalian, ChinaNo longer taking part
  • Dandong Central HospitalDandong, ChinaNo longer taking part
  • Dandong First HospitalDandong, ChinaNo longer taking part
  • DA QING LongNan HospitalDaqing, ChinaNo longer taking part
  • Daqing No.4 hospitalDaqing, ChinaNo longer taking part
  • Daqing Oilfield General HospitalDaqing, ChinaNo longer taking part
  • Ningjin People's HospitalDezhou, ChinaNo longer taking part
  • People's Hospital of Qihe CountyDezhou, ChinaNo longer taking part
  • Minxian County Hospital of Traditional Chinese MedicineDingxi, ChinaNo longer taking part
  • The Second People's Hospital of DongyingDongying, ChinaNo longer taking part
  • Liaoning Health Industry Group Fukuang General HospitalFushun, ChinaNo longer taking part
  • Fuyang People's HospitalFuyang, ChinaNo longer taking part
  • The Second Affiliated Hospital of Hainan Medical UniversityHaikou, ChinaNo longer taking part
  • Cixian People's HospitalHandan, ChinaNo longer taking part
  • Handan Central HospitalHandan, ChinaNo longer taking part
  • Qiuxian County People's HospitalHandan, ChinaNo longer taking part
  • Weixian People's HospitalHandan, ChinaNo longer taking part
  • Beian No.1 People's HospitalHarbin, ChinaNo longer taking part
  • The 2nd Affiliated Hospital of Harbin Medical UniversityHarbin, ChinaNo longer taking part
  • The First Affiliated Hospital of Harbin Medical UniversityHarbin, ChinaNo longer taking part
  • Hebi Coal Industry (Group) Co., Ltd. General HospitalHebi, ChinaNo longer taking part
  • No.1 People'S Hospital of HeiheHeihe, ChinaNo longer taking part
  • Hejian People's HospitalHejian, ChinaNo longer taking part
  • Hengshui People's HospitalHengshui, ChinaNo longer taking part
  • The NO.4 People's Hospital of HengshuiHengshui, ChinaNo longer taking part
  • Yuncheng County People's HospitalHeze, ChinaNo longer taking part
  • Tuoketuo County HospitalHohhot, ChinaNo longer taking part
  • Lianshui County People's HospitalHuai'an, ChinaNo longer taking part
  • Huidong People's HospitalHuizhou, ChinaNo longer taking part
  • Huizhou First HospitalHuizhou, ChinaNo longer taking part
  • Huludao Central HospitalHuludao, ChinaNo longer taking part
  • Huzhou Central HospitalHuzhou, ChinaNo longer taking part
  • The First Affiliated Hospital of Jiamusi UniversityJiamusi, ChinaNo longer taking part
  • The Hongda Hospital of Jiamusi UniversityJiamusi, ChinaNo longer taking part
  • Jiaozuo Coal Mining Group Co., Ltd. Central HospitalJiaozuo, ChinaNo longer taking part
  • Mengzhou Fuxing hospitalJiaozuo, ChinaNo longer taking part
  • Mengzhou Hospital of Traditional Chinese MedicineJiaozuo, ChinaNo longer taking part
  • Qinyang City Hospital of Traditional Chinese MedicineJiaozuo, ChinaNo longer taking part
  • Qinyang People's HospitalJiaozuo, ChinaNo longer taking part
  • The First Affiliated Hospital of Henan Polytechnic University (Jiaozuo Second People's Hospital)Jiaozuo, ChinaNo longer taking part
  • Xiuwu County People's HospitalJiaozuo, ChinaNo longer taking part
  • Haiyan People's HospitalJiaxing, ChinaNo longer taking part
  • The First People's Hospital of JingdezhenJingdezhen, ChinaNo longer taking part
  • Qufu People's HospitalJining, ChinaNo longer taking part
  • Jiujiang No.1 People's HospitalJiujiang, ChinaNo longer taking part
  • Shanghai General Hospital Jiuquan HospitalJiuquan, ChinaNo longer taking part
  • Mudanjiang Hospital of Beidahuang GroupJixi, ChinaNo longer taking part
  • Jiyuan Hospital of Traditional Chinese MedicineJiyuan, ChinaNo longer taking part
  • The People's Hospital of the Qiandongnan Miao and Dong Autonomous PrefectureKaili, ChinaNo longer taking part
  • Gansu Provincial Maternity and Child-care Hospital(Gansu Provincial Central Hospital)Lanzhou, ChinaNo longer taking part
  • The First People's Hospital of Yuzhong CountyLanzhou, ChinaNo longer taking part
  • Liaocheng Brain HospitalLiaocheng, ChinaNo longer taking part
  • Liaocheng City Central HospitalLiaocheng, ChinaNo longer taking part
  • Liaocheng People's HospitalLiaocheng, ChinaNo longer taking part
  • The People's Hospital of GaotangLiaocheng, ChinaNo longer taking part
  • The people's Hospital of LinqingLiaocheng, ChinaNo longer taking part
  • The Third People Hospital in LiaochengLiaocheng, ChinaNo longer taking part
  • Linfen Central HospitalLinfen, ChinaNo longer taking part
  • Lishui Central HospitalLishui, ChinaNo longer taking part
  • Liuzhou Worker's HospitalLiuzhou, ChinaNo longer taking part
  • Lianyuan People's HospitalLoudi, ChinaNo longer taking part
  • Luoyang Central HospitalLuoyang, ChinaNo longer taking part
  • Luoyang First People's HospitalLuoyang, ChinaNo longer taking part
  • The Second Affiliated Hospital of Henan University of Science and TechnologyLuoyang, ChinaNo longer taking part
  • Meihekou Central HospitalMeihekou, ChinaNo longer taking part
  • Meishan Cardio Cerebrovascular Disease HospitalMeishan, ChinaNo longer taking part
  • People'S Hospital of TangheNanyang, ChinaNo longer taking part
  • Ningde People's HospitalNingde, ChinaNo longer taking part
  • The People's Hospital of Nujiang Lisu Autonomous PrefectureNujiang, ChinaNo longer taking part
  • Pingdingshan The second people's hospitalPingdingshan, ChinaNo longer taking part
  • The First People's Hospital of PingdingshanPingdingshan, ChinaNo longer taking part
  • Ninger People's HospitalPu'er, ChinaNo longer taking part
  • Chinese Medicine Hospital of PuyangPuyang, ChinaNo longer taking part
  • Nanle People's HospitalPuyang, ChinaNo longer taking part
  • Puyang County People's HospitalPuyang, ChinaNo longer taking part
  • Puyang Oilfield General HospitalPuyang, ChinaNo longer taking part
  • Puyang People's HospitalPuyang, ChinaNo longer taking part
  • Qingdao Cardiovascular Hospital Co., Ltd.Qingdao, ChinaNo longer taking part
  • The Second Hospital of QinhuangdaoQinhuangdao, ChinaNo longer taking part
  • Tianjin Cancer Hospital Qinhuangdao BranchQinhuangdao, ChinaNo longer taking part
  • The Second Affiliated Hospital of Qiqihar Medical UniversityQiqihar, ChinaNo longer taking part
  • Sanmenxia Central HospitalSanmenxia, ChinaNo longer taking part
  • The First People Hospital of LingbaoSanmenxia, ChinaNo longer taking part
  • Yellow River Sanmenxia HospitalSanmenxia, ChinaNo longer taking part
  • Liqun Hospital, Putuo District, ShanghaiShanghai, ChinaNo longer taking part
  • Shanghai Fourth People's Hospital Affiliated to Tongji UniversityShanghai, ChinaNo longer taking part
  • Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of MedicineShanghai, ChinaNo longer taking part
  • People's hospital of NingLingShangqiu, ChinaNo longer taking part
  • Shang Qiu Hospital of TcmShangqiu, ChinaNo longer taking part
  • Sui county traditional Chinese medicine hospitalShangqiu, ChinaNo longer taking part
  • Yugan Xinjiang hospitalShangrao, ChinaNo longer taking part
  • Shaoguan Qujiang District People's HospitalShaoguan, ChinaNo longer taking part
  • Shaoxing People's HospitalShaoxing, ChinaNo longer taking part
  • Shenmu HospitalShenmu, ChinaNo longer taking part
  • Central Hospital Affiliated to Shenyang Medical CollegeShenyang, ChinaNo longer taking part
  • Northern Theater Command Air Force HospitalShenyang, ChinaNo longer taking part
  • Northern Theater Command General HospitalShenyang, ChinaNo longer taking part
  • The First People's Hospital of ShenyangShenyang, ChinaNo longer taking part
  • The People's Hospital of Liaoning ProvinceShenyang, ChinaNo longer taking part
  • The Second Hospital of Hebei Medical UniversityShijiazhuang, ChinaNo longer taking part
  • Xingtang County People's HospitalShijiazhuang, ChinaNo longer taking part
  • Xinji Traditional Chinese Medicine HospitalShijiazhuang, ChinaNo longer taking part
  • The Fifth People's Hospital of NingxiaShizuishan, ChinaNo longer taking part
  • The third hospital of shi zui shanShizuishan, ChinaNo longer taking part
  • Hongxinglong Hospital of Beidahuang GroupShuangyashan, ChinaNo longer taking part
  • Grand Hospital of ShuozhouShuozhou, ChinaNo longer taking part
  • Siping City Central People's HospitalSiping, ChinaNo longer taking part
  • Suining Center HospitalSuining, ChinaNo longer taking part
  • Siyang Kangda HospitalSuqian, ChinaNo longer taking part
  • The Second Affiliated Hospital of Shandong First Medical UniversityTai’an, ChinaNo longer taking part
  • First Hospital of Shanxi Medical UniversityTaiyuan, ChinaNo longer taking part
  • Second hospital of Shanxi Medical UniversityTaiyuan, ChinaNo longer taking part
  • Shanxi Cardiovascular HospitalTaiyuan, ChinaNo longer taking part
  • Guye District Hospital of Traditional Chinese Medicine, TangshanTangshan, ChinaNo longer taking part
  • Yutian County Hospital of Traditional Chinese MedicineTangshan, ChinaNo longer taking part
  • First People's Hospital of TianshuiTianshui, ChinaNo longer taking part
  • The First Hospital of Xifeng CountyTieling, ChinaNo longer taking part
  • Tonghua Dongchang District People's HospitalTonghua, ChinaNo longer taking part
  • Tongliao People's HospitalTongliao, ChinaNo longer taking part
  • Tongren People's HospitalTongren, ChinaNo longer taking part
  • Xinjiang Production&Construaction Corps HospitalÜrümqi, ChinaNo longer taking part
  • People's Hospital of Changle CountyWeifang, ChinaNo longer taking part
  • People's Hospital of GaomiWeifang, ChinaNo longer taking part
  • Weifang People's HospitalWeifang, ChinaNo longer taking part
  • Weihai Central HospitalWeihai, ChinaNo longer taking part
  • Weihai Wendeng District People's HospitalWeihai, ChinaNo longer taking part
  • Affiliated Yueqing Hospital of Wenzhou Medical UniversityWenzhou, ChinaNo longer taking part
  • Department of Yongjia People's HospitalWenzhou, ChinaNo longer taking part
  • Zhongnan Hospital of Wuhan UniversityWuhan, ChinaNo longer taking part
  • The First Affiliated Hospital of Wannan Medical CollegeWuhu, ChinaNo longer taking part
  • The Second Affiliated Hospital of Xi'an Medical UniversityXi'an, ChinaNo longer taking part
  • Xi 'an Fengcheng HospitalXi'an, ChinaNo longer taking part
  • Xianning Central HospitalXianning, ChinaNo longer taking part
  • Qinghe people's hospitalXingtai, ChinaNo longer taking part
  • Weixian People's HospitalXingtai, ChinaNo longer taking part
  • Xingtai central hospitalXingtai, ChinaNo longer taking part
  • Xingtai People's HospitalXingtai, ChinaNo longer taking part
  • Qinghai Provincial Traffic HospitalXining, ChinaNo longer taking part
  • The First Affiliated Hospital of Henan Medical UniversityXinxiang, ChinaNo longer taking part
  • People's Hospital of XixianXinyang, ChinaNo longer taking part
  • Changge People's HospitalXuchang, ChinaNo longer taking part
  • Inner Mongolia Forestry General HospitalYakeshi, ChinaNo longer taking part
  • Zichang People's HospitalYan’an, ChinaNo longer taking part
  • The First People's Hospital of YangquanYangquan, ChinaNo longer taking part
  • Qixia Traditional Chinese Medicine HospitalYantai, ChinaNo longer taking part
  • Yantai Hospital of Traditional Chinese MedicineYantai, ChinaNo longer taking part
  • Yantai Penglai traditional Chinese medicine hospitalYantai, ChinaNo longer taking part
  • Yantai Taocun Central HospitalYantai, ChinaNo longer taking part
  • Yantai Yuhuangding HospitalYantai, ChinaNo longer taking part
  • YEDA hospitalYantai, ChinaNo longer taking part
  • Jiang'an County Hospital of Traditional Chinese MedicineYibin, ChinaNo longer taking part
  • The Affiliated Hospital of Yongzhou Vocational and Technical CollegeYongzhou, ChinaNo longer taking part
  • Zhalantun Hospital of Traditional Chinese and Mongolian MedicineZhalantun, ChinaNo longer taking part
  • Zhalantun People's HospitalZhalantun, ChinaNo longer taking part
  • Xuangang HospitalZhangjiakou, ChinaNo longer taking part
  • Wuchuan People's HospitalZhanjiang, ChinaNo longer taking part
  • Xingyang People's HospitalZhengzhou, ChinaNo longer taking part
  • Xinmi Hospital of T.C.MZhengzhou, ChinaNo longer taking part
  • Taikang Xian People's HospitalZhoukou, ChinaNo longer taking part
  • Zhoukou Yongshan HospitalZhoukou, ChinaNo longer taking part
  • The First People's Hospital of ZhumadianZhumadian, ChinaNo longer taking part
  • The People's Hospital Of Biyang CountyZhumadian, ChinaNo longer taking part
  • The People's Hospital of Queshan CountyZhumadian, ChinaNo longer taking part
  • Zhumadian Central HospitalZhumadian, ChinaNo longer taking part

Questions to ask the study team

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Trial details

Who runs it
Beijing Tiantan Hospital
Trial code
NCT07242599
Record updated
16 April 2026
Original description
The Oris trial aims to evaluate whether the use of Ongericimab injection in patients with atherosclerotic ischemic cerebrovascular disease within 3 months of onset can reduce the risk of recurrent major cardiovascular events by achieving lower lipid-lowering target values (LDL-C < 1.4 mmol/L).Read full original descriptionShow less

A Multicenter, Randomized, Open-label, Parallel-controlled, Event-driven, Blinded-endpoint Trial Evaluating the Efficacy and Safety of Ongericimab Injection in High-risk Stroke Patients With Intracranial or Extracranial Atherosclerotic Stenosis.

The Oris trial aims to evaluate whether the use of Ongericimab injection in patients with atherosclerotic ischemic cerebrovascular disease within 3 months of onset can reduce the risk of recurrent major cardiovascular events by achieving lower lipid-lowering target values (LDL-C < 1.4 mmol/L).

Inclusion: Obtaining informed consent；; Age ≥18 years；; Patients with ischemic stroke within 3 months( NIHSS<15 before randomization); Presence of ≥50% stenosis in major intracranial or extracranial arteries, and related to the symptoms of the current episode or the location of infarction；; LDL-C ≥ 70 mg/dL (1.8 mmol/L) at screening.

Exclusion: Hypothyroidism diagnosed within 1 month before randomization; NYHA Class III/IV heart failure within 1 year prior to randomization; PCSK9 inhibitor use within 3 months before randomization; Participation in other drug/device trials within 30 days; History of cerebral hemorrhage at any time (microhemorrhages present only on SWI are not an exclusion criterion); Hemorrhage or other pathological neurological conditions on baseline brain CT/MRI (e.g., vascular malformations, tumors, abscesses, or common non-ischemic brain diseases like multiple sclerosis); Stroke caused by angioplasty/vascular surgery; Cardioembolic stroke caused by atrial fibrillation, artificial heart valves, endocarditis, mitral stenosis, sinus node dysfunction, etc; Uncontrolled hypertension (SBP >180 mmHg or DBP >110 mmHg); Malignancy within 10 years (excluding adequately treated basal cell carcinoma, cervical CIS, DCIS, or stage 1 prostate cancer); Known hypersensitivity to monoclonal antibody therapies; Inability to understand or comply with the study due to mental illness, cognitive, or emotional disorders, or other reasons deemed unsuitable for participation in the study by the investigator; Most recent fasting triglycerides >400 mg/dL (4.5 mmol/L) prior to randomization; Severe renal impairment (eGFR <30 mL/min/1.73m²); Active liver disease or dysfunction (AST/ALT >3×ULN within 30 days pre-randomization); Life-limiting non-cardiovascular diseases (life expectancy <1 years); Presence of isolated sensory symptoms (e.g., numbness), isolated visual changes, or isolated dizziness or vertigo, but no evidence of recent infarction on baseline head CT or MRI; Unable to complete the assessment of intracranial and extracranial arterial stenosis before randomization; mRS score≥2 before onset (based on assessment of medical history); Women of childbearing potential without contraception, pregnancy, or lactation.

ClinicalTrials.gov NCT07242599