First study of DEG6498 in adults with advanced solid tumors
Tests the safety of DEG6498, taken by mouth, in advanced solid tumors.
Plain-language title generated from the registry record
Registry title: A Study of DEG6498 in Participants With Solid Tumors
Key facts
- Where
- Beijing and Guangzhou, ChinaSee the 3 sites
- Phase
- Phase 1
Where in China
- Beijing Cancer HospitalBeijing, ChinaTaking people
- Beijing GoBroad HospitalBeijing, ChinaTaking people
- Sun Yat-sen University Cancer CenterGuangzhou, ChinaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Degron Therapeutics Co.
- Trial code
- NCT07244835
- Record updated
- 30 June 2026
- Original description
The goal of this first in human, Phase 1, multi-center, open-label, and 2-part study is to learn whether DEG6498 is safe and tolerable in participants with advanced solid tumors. It will also learn about DEG6498 pharmacokinetics (PK) profile and potential antitumor activity. The main questions it aims to answer are:Read full original descriptionShow less
A First in Human Phase 1 Open-Label, Multicenter, Dose Escalation and Expansion Study of DEG6498 in Patients With Solid Tumors
The goal of this first in human, Phase 1, multi-center, open-label, and 2-part study is to learn whether DEG6498 is safe and tolerable in participants with advanced solid tumors. It will also learn about DEG6498 pharmacokinetics (PK) profile and potential antitumor activity. The main questions it aims to answer are:
* what is an appropriate dose to be given to participants? * are the side effects of treatment manageable?
Participants who are treated in this study will receive DEG6498 orally once a day and be closely monitored by the treating physicians.
Inclusion: Willing and able to provide written informed consent for the study prior to the performance of any study-specific procedures; Male and female older than or equal to 18 years of age at the time signing the informed consent form (ICF); If female, must be postmenopausal, or surgically sterile, or agree to highly effective contraceptive measures to prevent pregnancy throughout treatment period and within 30 days of last study drug treatment; Women of childbearing potential (WOCBP) must have 2 negative pregnancy tests (1 serum test required) as verified by the investigator prior to starting study drug; If male, must agree to inform and ensure their female partners to use highly effective contraception measures to prevent pregnancy, and to refrain from donating sperm while on study drug and for at least 30 days following DEG6498 discontinuation; Patients with advanced solid tumors, who have failed standard therapies, or for whom no standard therapy exists; Part 1: Advanced solid tumor patients; Part 2: Patients with BRAF mutation positive tumors and HCC; Presence of at least 1 measurable lesion according to RECIST v1.1 ; Has an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.
Exclusion: Active or concurrent malignancy requiring treatment (including both systemic therapy and radiotherapy) within 14 days or 5 half lives (whichever is shorter) prior to the first dose of study drug, or received antibody therapy within 28 days; Symptomatic CNS metastases which are neurologically unstable, or CNS metastases requiring local CNS directed therapy, or increasing doses of corticosteroids within 2 weeks of first dose of study treatment; Participant has a condition that confounds the ability for interpret data from the study; Clinically significant cardiovascular disease; Known active or chronic infection that requires systemic therapy within 2 weeks of first dose of study drug; Known human immunodeficiency virus (HIV) infection or known acquired immunodeficiency syndrome, or active HBV or HCV infection; Participant has a significant medical condition, laboratory abnormality, or psychiatric illness that would prevent the participant from participating in the study, puts the participant at unacceptable risk if he/she were to participate in the study; Pregnant or breastfeeding women.