N-acetylcysteine and simethicone to improve the view during stomach and upper gut endoscopy
Tests whether these two medicines improve the view during upper endoscopy in adults.
Plain-language title generated from the registry record
Registry title: Premedication With N-acetylcysteine and Simethicone to Improve Mucosal Visualization in Elective Upper Endoscopy
Key facts
- Where
- Mexicali, MexicoSee the 2 sites
- Phase
- Phase 2
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 99 years old?
Source: NCT07245095, who can take part
Where in Mexico
- Hospital AlmaterMexicali, MexicoTaking people
- Hospital General de MexicaliMexicali, MexicoTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Hospital General de Mexicali
- Trial code
- NCT07245095
- Record updated
- 24 November 2025
- Original description
The goal of this randomized, double-blind, placebo-controlled clinical trial is to assess whether the combination of N-acetylcysteine and simethicone improves mucosal visibility during upper gastrointestinal endoscopy in adults aged 18 to 99 years of both sexes, including both healthy individuals and those with non-bleeding gastrointestinal symptoms.Read full original descriptionShow less
Randomized Controlled Trial to Evaluate the Effect of Premedication With N-acetylcysteine and Simethicone on Mucosal Visibility During Elective Upper Gastrointestinal Endoscopy Using the TUGS Score
The goal of this randomized, double-blind, placebo-controlled clinical trial is to assess whether the combination of N-acetylcysteine and simethicone improves mucosal visibility during upper gastrointestinal endoscopy in adults aged 18 to 99 years of both sexes, including both healthy individuals and those with non-bleeding gastrointestinal symptoms.
The main questions this study aims to answer are:
Does pre-endoscopy administration of N-acetylcysteine/simethicone improve mucosal visualization based on the Toronto Upper Gastrointestinal Cleanliness Score (TUGS)?
Is this combination safe and well tolerated in this patient population?
Researchers will compare patients receiving N-acetylcysteine (600 mg) and simethicone (100 mg) orally 20-60 minutes before the procedure with those receiving placebo (water) to determine if there is a significant improvement in TUGS scores.
Participants will:
Receive a single oral dose of either N-acetylcysteine/simethicone or placebo prior to endoscopy
Undergo a routine upper GI endoscopy
Have mucosal cleanliness evaluated using the TUGS scoring system
Be monitored for any adverse events or intolerance
Inclusion: Men and women aged 18 to 70 years old; Patients who agree to participate in the clinical trial; Patients without active gastrointestinal bleeding; Signing of informed consent form.
Exclusion: Patients with a previous endoscopic diagnosis; Patients taking medications that delay gastric emptying (GLP-1 analogues); Patients with a history of hypersensitivity to N-acetylcysteine; Patients with a history of hypersensitivity to simethicone; Patients with a history of gastric or bariatric surgery; Patients with a history of motor disorders (e.g., scleroderma, diabetic gastroparesis); Pregnant or breastfeeding patients; Patients who do not agree to participate in the clinical trial.