Quantitative brain MRI at 3 Tesla and 7 Tesla in multiple sclerosis
Develops quantitative MRI brain scans for people with multiple sclerosis and healthy adults.
Plain-language title generated from the registry record
Registry title: Evaluation of the Clinical Contribution of Quantitative MRI in Neuro-imaging
Key facts
- Where
- Montpellier, FranceSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 52 years old?
Source: NCT07245589, who can take part
Where in France
- Hôpital Gui de ChauliacMontpellier, FranceNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Assistance Publique Hopitaux De Marseille
- Trial code
- NCT07245589
- Record updated
- 24 November 2025
- Original description
This study aims to develop the use of a quantitative MRI (qMRI) approach in neuroimaging for MS patients.Read full original descriptionShow less
Development of Quantitative MRI Neuroimaging Protocols at High Fields (3 Tesla) and Ultra-high Fields (7 Tesla) for Clinical Evaluation: Application to Multiple Sclerosis
This study aims to develop the use of a quantitative MRI (qMRI) approach in neuroimaging for MS patients.
To achieve this task the main goals of this study will be:
* to standardize and optimize qMRI protocols (acquisition time, sensitivity) * to acquire ranges of normative values of qMRI parameters as a function of age and sex at high fields (3 Tesla) and ultra-high fields (UHF for ultra-high field, 7 Tesla) * To develop integrated tools for image processing and the generation of normative models of the healthy brain normative values * To assess the clinical feasibility and the multicenter validation of the multiparametric tools proposed in the case of application to MS.
Inclusion: For healthy volunteers :; Male or female aged 20 to 50; Subject with no history of previous or concomitant neurological and psychiatric diseases at the time of inclusion; Subject without a history of traumatic brain injury; Subject with no vascular history (arterial hypertension, stroke) or concomitant at the time of its inclusion; Subject has no history of chronic drug and/or alcohol abuse; Subject having received information regarding the study and having signed an informed consent; Beneficiary or entitled person to a social security scheme; For MS patients; Male or female aged 18 to 52; Patient diagnosed with MS according to the; criteria of McDonald 2017; Patient presenting a maximum EDSS of 6; Patient with MS for less than 10 years of evolution; Patient having received information regarding the study and having signed an informed consent; Patient beneficiary or entitled to a plan of social security.
Exclusion: For healthy subjects :; Subject presenting a contraindication to performing an MRI: pacemaker, presence of metal implants, claustrophobia; Subject unable to maintain a supine position for a prolonged period; Subject in a period of exclusion from another research protocol at the time of signing consent/non-opposition form; Subjects covered by articles L1121-5 to 1121-8 of the Public Health Code (minor patient, adult patient under guardianship or curatorship, patient deprived of liberty, pregnant or breastfeeding woman); For MS patients; Subject presenting a contraindication to performing an MRI: pacemaker, presence of metal implants, claustrophobia; Subject unable to maintain a supine position for a prolonged period; Subject in a period of exclusion from another research protocol at the time of signing consent/non-opposition form; Subjects covered by articles L1121-5 to 1121-8 of the Public Health Code (minor patient, adult patient under guardianship or curatorship, patient deprived of liberty, pregnant or breastfeeding woman).