Using a newer MRI scan method to help diagnose prostate cancer
Tests a newer MRI scan in people with suspected prostate cancer.
Plain-language title generated from the registry record
Registry title: MR Microstructural Imaging for Prostate Cancer Diagnosis
Key facts
- Where
- Beijing, Dalian, Hangzhou, Nanjing, and Zhengzhou, ChinaSee the 6 sites
Where in China
- Beijing HospitalBeijing, ChinaTaking people
- The First Affiliated Hospital of Dalian Medical UniversityDalian, ChinaTaking people
- The First Affiliated Hospital Zhejiang University School of MedicineHangzhou, ChinaTaking people
- Zhejiang HospitalHangzhou, ChinaTaking people
- The First Affiliated Hospital of Nanjing Medical University (Jiangsu Province Hospital)Nanjing, ChinaTaking people
- Henan Cancer Hospital,Affiliated Cancer Hospital of Zhengzhou UniversityZhengzhou, ChinaNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- First Affiliated Hospital of Zhejiang University
- Trial code
- NCT07249281
- Record updated
- 25 November 2025
- Original description
The goal of this multi-center clinical study is to evaluate whether time-dependent diffusion MRI (TDDMRI) can provide reliable microstructural imaging markers for the diagnosis of prostate cancer. The main questions this study aims to answer are:Read full original descriptionShow less
Development of MR Microstructural Imaging Markers for Prostate Cancer Diagnosis and Investigation of the Associated Molecular Mechanisms
The goal of this multi-center clinical study is to evaluate whether time-dependent diffusion MRI (TDDMRI) can provide reliable microstructural imaging markers for the diagnosis of prostate cancer. The main questions this study aims to answer are:
* Do TDDMRI-derived microstructural parameters (such as cell size and density) improve diagnostic accuracy for prostate cancer compared with conventional MRI? * How well do the microstructural parameters correlate with whole-slide pathology findings? * Can the investigators determine diagnostic models combining multiple features for presurgical diagnosis across multiple centers?
Participants with suspected prostate cancer will undergo 3T MRI including TDDMRI. Microstructural parameters will be quantified and compared with standard multiparametric MRI. All participants will also receive prostate biopsy or prostatectomy, and imaging findings will be validated against histopathology.
This study will:
* Collect TDDMRI and conventional MRI data from six hospitals. * Derive and validate imaging markers of prostate cancer based on microstructural parameters. * Compare diagnostic performance across centers and against pathology as the reference standard.
Inclusion: Clinical suspicion of prostate cancer (elevated PSA, abnormal digital rectal examination, or other clinical indication); Undergoing prostate MRI including TDDMRI as part of diagnostic evaluation. Able and willing to provide written informed consent.
Exclusion: Contraindications to MRI (e.g., pacemaker, ferromagnetic implants, severe claustrophobia); Prior treatment for prostate cancer (surgery, radiation, hormonal therapy, chemotherapy); Severe comorbid conditions precluding MRI or biopsy; Inability to provide informed consent; Poor image quality due to motion or technical artifacts (assessed at imaging QC).