Two Pacemaker Lead Positions and Atrial Rhythm Episodes in People With Heart Block
Compares two pacemaker pacing sites for atrial rhythm episodes in people needing frequent pacing.
Plain-language title generated from the registry record
Registry title: Left Bundle Branch Pacing vs Right Ventricular Pacing on AHRE Burden in Patients With Preserved LVEF
Key facts
- Where
- Pátrai, GreeceSee the site
Where in Greece
- University General Hospital of PatrasPátrai, GreeceTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University Hospital of Patras
- Trial code
- NCT07250529
- Record updated
- 13 March 2026
- Original description
This prospective, randomized controlled trial aims to evaluate the effect of left bundle branch pacing (LBBP) compared with conventional right ventricular (RV) pacing on the cumulative duration (total time) of atrial high-rate episodes (AHREs) in patients with preserved left ventricular ejection fraction (LVEF) who are expected to require frequent ventricular pacing.Read full original descriptionShow less
Comparison of Left Bundle Branch Pacing Versus Conventional Right Ventricular Pacing on AHRE Burden in Patients With Preserved Left Ventricular Ejection Fraction and High Ventricular Pacing Dependency (LBBP-AHRE Trial): A Randomized Study
This prospective, randomized controlled trial aims to evaluate the effect of left bundle branch pacing (LBBP) compared with conventional right ventricular (RV) pacing on the cumulative duration (total time) of atrial high-rate episodes (AHREs) in patients with preserved left ventricular ejection fraction (LVEF) who are expected to require frequent ventricular pacing.
Atrial High-Rate Episodes (AHREs) are defined as episodes of atrial tachyarrhythmia that are automatically recorded by device diagnostics and detected by implanted cardiac devices. These episodes usually have an atrial rate ≥170 beats per minute and a duration ≥6 minutes. AHREs are linked to a higher risk of thromboembolic events and clinical atrial fibrillation (AF), and they may indicate subclinical AF or other atrial tachyarrhythmias.
Chronic RV pacing has been linked to mechanical and electrical dyssynchrony, which may encourage atrial remodeling and the development of AF. LBBP provides a more physiological ventricular activation and may reduce atrial tachyarrhythmia time (AHRE time).
Patients with LVEF >50% and atrioventricular (AV) conduction disorders requiring a dual-chamber pacemaker will be randomized to either conventional RV septal pacing or LBBP.
Inclusion: Age ≥ 18 years; Scheduled implantation of a dual-chamber pacemaker for:; Permanent complete heart block Permanent second-degree AV block (Mobitz II or Mobitz I); Documented preserved LVEF (≥50%); Sinus rhythm at baseline; Ability to provide written informed consent.
Exclusion: Previous atrial fibrillation ablation (catheter-based or surgical); Requirement for antiarrhythmic therapy for causes other than atrial fibrillation; History of paroxysmal, persistent, or permanent atrial fibrillation; Sinus node disease; Significant structural or valvular heart disease; Existing pacemaker or other cardiac device requiring modification for study participation; Any condition judged by the investigator to compromise participation or the integrity of study data; LVEF < 50%; Transient AV block requiring pacemaker implantation; Requirement for pacemaker system upgrade during the study period; Enrollment in another clinical trial that could interfere with study endpoints or pacing parameters; Contraindication to LBBP or associated lead implantation procedure; Life expectancy < 12 months.