A Supervised Exercise Program for People With Heart Failure With Preserved Ejection Fraction
Tests a supervised exercise program in adults with heart failure with preserved ejection fraction.
Plain-language title generated from the registry record
Registry title: Effects of a Multicomponent Training Program on Cardiac Function, Skeletal Muscle Metabolism, Functional Capacity, and Quality of Life in Patients With HFpEF: SENSORFIT-4HEART Study
Key facts
- Where
- Pamplona, SpainSee the site
Where in Spain
- Universidad Pública de Navarra (UPNA)Pamplona, SpainNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Universidad Pública de Navarra
- Trial code
- NCT07251361
- Record updated
- 26 November 2025
- Original description
Heart failure with preserved ejection fraction (HFpEF) is a complex syndrome with increasing incidence and poor prognosis, accounting for up to 50% of heart failure cases. It is strongly associated with aging, cardiovascular risk factors (hypertension, diabetes, obesity), and is more prevalent in women than men. Patients with HFpEF frequently present with dyspnea, debilitating fatigue, poor quality of life, frequent hospitalizations, and high mortality rates. This study aims to evaluate the effects of a structured exercise program on cardiac function, skeletal muscle metabolism, functional capacity, and quality of life in patients with HFpEF, and to explore whether these benefits are mediated by circulating exerkines.Read full original descriptionShow less
SENSORFIT-4HEART: Smart Exercise preScriptiOn and Remote Monitoring FITness Platform for HEART Failure With Preserved Ejection Fraction
Heart failure with preserved ejection fraction (HFpEF) is a complex syndrome with increasing incidence and poor prognosis, accounting for up to 50% of heart failure cases. It is strongly associated with aging, cardiovascular risk factors (hypertension, diabetes, obesity), and is more prevalent in women than men. Patients with HFpEF frequently present with dyspnea, debilitating fatigue, poor quality of life, frequent hospitalizations, and high mortality rates. This study aims to evaluate the effects of a structured exercise program on cardiac function, skeletal muscle metabolism, functional capacity, and quality of life in patients with HFpEF, and to explore whether these benefits are mediated by circulating exerkines.
Inclusion: Patients diagnosed with heart failure with preserved ejection fraction according to 2021 ESC guidelines for Heart Failure; Left ventricular ejection fraction (LVEF) >40%, and/or evidence of structural and/or functional cardiac abnormality (diastolic dysfunction, elevated filling pressures, BMI>30 kg/m2); Elevated natriuretic peptides (BNP ≥35 pg/mL or NT-proBNP ≥125 pg/mL); Stable symptomatic heart failure patients (New York Heart Association functional class II-III/IV) during the last month.
Exclusion: Participation in cardiac rehabilitation within the past 12 months; Significant pulmonary disease, including primary pulmonary hypertension; Severe chronic lung disease, including COPD requiring home oxygen, chronic nebulizer therapy, long-term oral steroids, or hospitalization for decompensated pulmonary disease within the past 12 months; Inability to comprehend study information or complete questionnaires (e.g., psychiatric disorder, dementia); Hemoglobin <10 g/dL; Contraindications to physical exercise training; Alternative diagnoses that could explain symptoms of HF (dyspnea, fatigue), in the judgment of the cardiologist; Body mass index (BMI) >40 kg/m²; Inability to perform a valid baseline cardiopulmonary exercise test.