NCT07253363Active, not recruiting
Circulating Activin-A and FSTL3 in Precapillary Pulmonary Hypertension
Investigation of Circulating ACTIvin-A and FSTL3 as Prognostic and Predictive BIOmarkers in Precapillary Pulmonary Hypertension
Source: ClinicalTrials.gov · Last updated 28 Nov 2025
Brief summary (registry, in English)
The ACTIOBIO study aims to evaluate the prognostic value of Activin-A and FSTL3 in a large cohort of patients with precapillary pulmonary hypertension, including pulmonary arterial hypertension (Group 1), pulmonary hypertension associated with lung diseases (Group 3), and chronic thromboembolic pulmonary hypertension (Group 4).
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 550 (estimated)
- First submitted
- 19 Nov 2025
- Start date
- 1 Mar 2024
- Primary completion date
- Apr 2026
- Lead sponsor
- Assistance Publique - Hôpitaux de Paris
- NCT number
- NCT07253363
What you commit to
- Study type: Interventional
- Planned participants: 550
- From 1 Mar 2024 to the primary completion date, Apr 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Criteria the registry did not label
- Male or female ≥ 18 years of age
- Precapillary PH documented by right heart catheterization:
- mean pulmonary arterial pressure (mPAP) \> 20 mmHg,
- pulmonary artery wedge pressure (PAWP) ≤ 15 mmHg;
- pulmonary vascular resistance (PVR) \> 2 WU
- Pulmonary arterial hypertension (group 1) or PH associated with lung disease (group 3) or chronic thromboembolic PH (group 4)
- Patient registered in the French PH registry
- Patient capable of understanding the study procedures
- Affiliation to a social security regime (or exemption)
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Hôpital Bicêtre (AP-HP.Université Paris-Saclay), Service de Pneumologie et Soins Intensifs Coordinator of this site? Confirm its status | Le Kremlin-Bicêtre | France | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.