Growing Lab Models of Endometrial Cancer From Surgical Tumor Samples
Tests whether tumor tissue from endometrial cancer surgery can be grown into lab models.
Plain-language title generated from the registry record
Registry title: Generation of Endometrial Carcinoma Organoids
Key facts
- Where
- Roma, ItalySee the site
Where in Italy
- IRCCS National Cancer Institute "Regina Elena"Roma, ItalyTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Regina Elena Cancer Institute
- Trial code
- NCT07258186
- Record updated
- 2 December 2025
- Original description
A prospective pilot genetic study to evaluate the feasibility of generating organoids from endometrial tumor tissue collected during surgery, performed according to standard clinical practice. Samples will be collected from collaborating extramural facilities, with the aim of analyzing the impact of transport on tissue viability and the success of organoid culture. This study is for exploratory purposes only, without altering the diagnostic and therapeutic pathways of the participants.Read full original descriptionShow less
Feasibility Study of the Generation of Endometrial Carcinoma Organoids From Tumor Samples Transferred From Extramural Facilities
A prospective pilot genetic study to evaluate the feasibility of generating organoids from endometrial tumor tissue collected during surgery, performed according to standard clinical practice. Samples will be collected from collaborating extramural facilities, with the aim of analyzing the impact of transport on tissue viability and the success of organoid culture. This study is for exploratory purposes only, without altering the diagnostic and therapeutic pathways of the participants.
Inclusion: Age >18 years; Patients with a histological diagnosis of: endometrial cancer, endometrioid histology, any stage of disease (FIGO I-IV), recurrence/metastasis from endometrial endometrioid cancer, and candidates for surgery and/or hysterectomy; Written informed consent (study participation and data processing) must be obtained in person and/or through a legal representative/guardian/support administrator/witness, before any study-specific procedure is performed.
Exclusion: Comorbidities not controlled with adequate medical therapy; Previous radiation treatments to the pelvic region; Endometrial cavity infections (pyometra); Synchronous tumors; Neoadjuvant treatments.