NCT07260071Recruiting
Hypertension in Children and Young People at Risk of Autosomal Dominant Polycystic Kidney Disease
Family Study of Early Hypertension in Children and Young People at Risk of Autosomal Dominant Polycystic Kidney Disease
Source: ClinicalTrials.gov · Last updated 4 Nov 2026
Brief summary (registry, in English)
The goal of this project is to measure the prevalence of Autosomal Dominant Polycystic Kidney Disease (ADPKD) and hypertension in the general population of children and young people at risk of ADPKD, using magnetic resonance imaging (MRI) for rapid diagnosis alongside genetic testing. The main question it aims to answer is: What is the prevalence of hypertension in a population sample of adolescents with ADPKD? Participants will have the following measurements performed: * Height and weight. * Blood pressure. * Non-invasive measurement of arterial stiffness. * Cardiac and renal MRI. * Blood sample. * Genetic testing.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 200 (estimated)
- First submitted
- 13 Nov 2025
- Start date
- 15 Aug 2025
- Primary completion date
- Mar 2028
- Lead sponsor
- King's College London
- NCT number
- NCT07260071
What you commit to
- Study type: Observational
- Planned participants: 200
- From 15 Aug 2025 to the primary completion date, Mar 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Presence of associated co-morbidities which make it difficult to interpret results, including congenital cardiac anomalies and known TSC-PKD1 mutations
Other
- 18 years or above at the time of study entry
- Unable to tolerate key study investigations
- Unwilling to undergo genetic testing for ADPKD
Who the study is looking for
- Age 12 - 17 years at the time of consent
- Able to tolerate the key study investigations (office blood pressure measurement, ambulatory blood pressure measurement, MRI and blood test)
- Parent with confirmed clinical diagnosis of ADPKD
- Parent (if child \<16 years) or both parent and young person (if \>=16 years) consents to genetic testing for ADPKD and demonstrates understanding of the implications of this.
Age in the registry: 12 years to 17 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Evelina London Children's Hospital Coordinator of this site? Confirm its status | London | United Kingdom | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.