Tests a saffron flower extract before a meal in adults with obesity and prediabetes
Tests a saffron flower water extract before a meal in people with obesity or prediabetes.
Plain-language title generated from the registry record
Registry title: Crocus Sativus Tepals Water Extract in Obesity and Prediabetes
Key facts
- Where
- Izola, SloveniaSee the site
- Phase
- Early phase 1
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 40 and 65 years old?
Source: NCT07261475, who can take part
Where in Slovenia
- University pf Primorska, Faculty of Health SciencesIzola, SloveniaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of Primorska
- Trial code
- NCT07261475
- Record updated
- 4 February 2026
- Original description
The goal of this clinical trial is to determine the acute effects of ingestion of a cold aqueous extract of Crocus sativus tepals on postprandial glycemia and other indicators of metabolic health in patients with obesity and/or prediabetes. The main questions it aims to answer are:Read full original descriptionShow less
Acute Effects of Water Extract of Crocus Sativus Tepals on Metabolic Health Parameters in Patients With Obesity and Prediabetes
The goal of this clinical trial is to determine the acute effects of ingestion of a cold aqueous extract of Crocus sativus tepals on postprandial glycemia and other indicators of metabolic health in patients with obesity and/or prediabetes. The main questions it aims to answer are:
* Does the ingestion of Crocus sativus tepals cold aqueous extract prior to a meal improve the glycemic response to a standard meal? * How does the ingestion of Crocus sativus tepals aqueous extract prior to a meal impact insulin levels and other markers of metabolic health? * Does the ingestion of Crocus sativus tepals cold aqueous extract prior to a meal increase the resting energy expanditure?
Researchers will compare Crocus sativus tepals cold aqueous extract to cold water.
The participants will visit the Faculty twice - on one visit they will ingest Crocus sativus tepals cold aqueous extract and on the other cold water (in random order) 5 minutes prior to a standard meal of 100 g of white bread.
On each visit, anthropometric measurements will be performed upon arrival. Blood samples will be collected 3 times, preceeded by resting metabolic rate and blood pressure measurements: at baseline in fasted conditions, and 60 minutes and 120 minutes after consuming the bread.
There will be an at least 7 days wash-out period between the two visits.
Inclusion: Obesity type I (ITM > 30 kg/m2) and/or; Prediabetes (fasting glucose levels 6,1 - 6,9 mmol/L).
Exclusion: Participation in another clinical trial 3 months prior to the study; electronic implant; Gastrointestinal diseases; Diabetes mellitus of any type; Serious clinical conditions such as cancer, severe infections, severe psychiatric disorders, autoimmune diseases, inflammatory diseases; Celiac disease of gluten intolerance; Pregnant or lactating, without contraception; ITM greater than 35 kg/m2.