Exercise With or Without Osteoporosis Medicine for Bone Health After Menopause
Tests home exercise, with or without bone medicine, in women with osteoporosis after menopause.
Plain-language title generated from the registry record
Registry title: Bone Health in Postmenopausal Women: The Effect of Exercise With or Without Medication for Osteoporosis
Key facts
- Where
- Loughborough, United KingdomSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 55 and 75 years old?
Source: NCT07267325, who can take part
Where in United Kingdom
- Loughborough UniversityLoughborough, United KingdomNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Loughborough University
- Trial code
- NCT07267325
- Record updated
- 5 December 2025
- Original description
Osteoporosis is a systemic bone disorder characterised by a reduced bone mass and structural deterioration, increasing the risk of fragility fractures, particularly in women post-menopause. Bone mass and structure can be assessed by scans.Read full original descriptionShow less
The Effect of Exercise With or Without Antiresorptive Therapy, on Bone Properties in Postmenopausal Women With Low BMD - Randomised Controlled Unilateral Intervention Trial
Osteoporosis is a systemic bone disorder characterised by a reduced bone mass and structural deterioration, increasing the risk of fragility fractures, particularly in women post-menopause. Bone mass and structure can be assessed by scans.
Antiresorptive medications are commonly prescribed to reduce bone resorption, preventing further bone loss and thus reducing the possibility of fracture. Exercise can also benefit bone mass and structure but current evidence do not show whether exercise is more, or less, effective in combination with antiresorptive medication.
This study will compare the effect of a brief, home-based exercise programme on bone mineral and structural properties in women taking/ not taking antiresorptive medication.
Inclusion: Women aged 55-75 years old; >4y since menopause/hysterectomy/oophorectomy; Baseline femoral neck or lumber spine BMD T-score between -1 and -3; Able to complete the hopping exercises; Have no regular involvement for more than once/week in:; Strength, powerlifting or high load resistance exercise; High to moderate impact exercise that known to involve ground reaction forces 2 to 4 times greater than body weight (e.g. Jogging); Treatment group: taking antiresorptive treatment for osteoporosis continuously for at least 12 months, and who intend to continue this medication for the rest of the study; Control group: not taking any medication affecting bone and no intention to commence such medication for the rest of the study.
Exclusion: Any medical condition, surgery, or injuries that contraindicate exercises including lower limb or back pain, knee or hip osteoarthritis; Body mass index (BMI) >35 kg/m2; Vertebral fracture or multiple low trauma fractures (recent expert consensus recommends lower impact exercise for these groups); Replacement of hip joint(s).