iPACK Block vs. Periarticular Infiltration for TKA Pain Control
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Source: NCT07267650, who can take part
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Print a page for my doctorTrial details
- Who runs it
- Turgutlu State Hospital
- Trial code
- NCT07267650
- Record updated
- 1 June 2026
- Original description
This study aims to retrospectively compare two different multimodal analgesic techniques for pain management after total knee arthroplasty (TKA). The primary purpose is to evaluate whether a combination of two specific nerve blocks administered by an anesthesiologist (Femoral Triangle Block + iPACK block) resulted in superior postoperative pain control compared to a hybrid combination of a nerve block and a local infiltration administered by the surgeon (FTB + Periarticular Infiltration [PAI]).Read full original descriptionShow less
Postoperative Analgesic Outcomes of iPACK Block Versus Periarticular Infiltration in Total Knee Arthroplasty: A Retrospective Cohort Study
This study aims to retrospectively compare two different multimodal analgesic techniques for pain management after total knee arthroplasty (TKA). The primary purpose is to evaluate whether a combination of two specific nerve blocks administered by an anesthesiologist (Femoral Triangle Block + iPACK block) resulted in superior postoperative pain control compared to a hybrid combination of a nerve block and a local infiltration administered by the surgeon (FTB + Periarticular Infiltration [PAI]).
The hypothesis is that the FTB + iPACK combination is associated with a significant reduction in Numeric Rating Scale (NRS) pain scores with movement at 24 hours postoperatively. This is a retrospective, observational cohort study conducted at a single center, involving medical records of patients who underwent primary unilateral TKA. Data from patients who received either FTB + iPACK or FTB + PAI as part of their standard clinical care will be extracted and analyzed retrospectively.
Inclusion: American Society of Anesthesiologists (ASA) physical status II-III; Scheduled for elective, primary, unilateral total knee arthroplasty for osteoarthritis; Able to provide written informed consent.
Exclusion: Known allergy to any study medications (local anesthetics, NSAIDs, tramadol, morphine, paracetamol); History of chronic opioid use (defined as daily use for >3 months); Severe renal or hepatic insufficiency; Cognitive impairment preventing the use of pain scales or questionnaires; Patient refusal to participate or contraindication to regional anesthesia; Pre-existing peripheral neuropathy in the operative limb; Revision or bilateral knee arthroplasty.