Heart rate lowering drugs before a heart CT scan for coronary artery disease
Compares metoprolol, atenolol and ivabradine for slowing the heart before a heart scan.
Plain-language title generated from the registry record
Registry title: Heart Rate Control Before Cardiac Computed Tomography in Adults for the Evaluation of Coronary Artery Disease
Key facts
- Where
- Herning, DenmarkSee the site
- Phase
- Phase 2/3
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 30 and 80 years old?
Source: NCT07268170, who can take part
Where in Denmark
- University Clinic of Ischemic Heart DiseaseHerning, DenmarkNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Gødstrup Hospital
- Trial code
- NCT07268170EU 2025-522741-21-00
- Record updated
- 17 December 2025
- Original description
The goal of this clinical trial is to describe which type and dose of commonly used heart rate reducing drugs (metoprolol, atenolol, or ivabradine) has the swiftest heart rate reduction from baseline in patients aged 30 to 80 years with a heart rate > 65 beats per minute undergoing cardiac computed tomography for the evaluation of coronary artery disease. The main question it aims to answer isRead full original descriptionShow less
Heart Rate Control: Betablockers or Ivabradine Therapy Before Cardiac Computed Tomography
The goal of this clinical trial is to describe which type and dose of commonly used heart rate reducing drugs (metoprolol, atenolol, or ivabradine) has the swiftest heart rate reduction from baseline in patients aged 30 to 80 years with a heart rate > 65 beats per minute undergoing cardiac computed tomography for the evaluation of coronary artery disease. The main question it aims to answer is
• Which type of heart reducing drug and dose has the swiftest heart rate reduction before cardiac computed tomography?
Inclusion: Individuals who are to undergo Cardiac CT; Sinus rhythm with heart rate > 65 bpm on ECG; Competent patients who have given written informed consent.
Exclusion: Previous percutaneous coronary intervention (with or without stent); Previous CABG; Regular treatment with beta-blockers; Regular treatment with ivabradine; Regular treatment with Cordarone; Concurrent treatment with potent inhibitors of CYP3A4; Concurrent treatment with potent inhibitors of MAO inhibitors,; Concurrent treatment with potent inhibitors of CYP2D6 inhibitors; Heart rate > 100 bpm; Known ischemic heart disease; Acute coronary syndrome; Known allergy to beta-blockers; Known allergy to ivabradine; Known allergy to used radiographic contrast agents; Sick sinus syndrome; Severe heart failure; Severe metabolic conditions; Heart failure with systolic left ventricular ejection fraction < 45%; Reduced kidney function with estimated glomerular filtration rate (eGFR) < 40 ml/min; Regular treatment with non-dihydropyridine calcium antagonists (Verapamil and Diltiazem); Concurrent treatment with potent inhibitors of intravenous calcium antagonists type I or III; Age > 80 years; Age < 30 years; BMI > 35; Pacemaker; Pregnant, including potentially pregnant, or breastfeeding (potentially pregnant patients will undergo pregnancy testing); Contraindications for beta-blockers or ivabradine:; Severe asthma; Severe COPD; Sinoatrial block (1st degree AV block); Advanced AV block (2nd or 3rd degree); Hypotension (systolic blood pressure < 110 mmHg); Severe restrictive cardiomyopathy; Severe aortic stenosis; Severe circulatory disturbances; Untreated pheochromocytoma.