Comparing Bypass Surgery and Stent Procedures for Heart Disease With Weak Heart Pumping
Compares bypass surgery with stenting in adults with blocked heart arteries and reduced heart function.
Key facts
- Who runs it
- University Medical Center Groningen
- Where
- Groningen, NetherlandsSee the site
- Trial code
- Registry title
- Surgical Versus Percutaneous Revascularization in Patients With Reduced Left Ventricular Function (STICH 3.0-NL)
- Status
- Recruiting
- People taking part
- 358 people, planned
- Started
- May 2026
- Expected to end
- May 2034
- Type of study
- Interventional, 2 groups
- Treatments tested
- CABG
- PCI
- Record updated
- 12 May 2026
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with a weak heart pump and narrowed coronary arteries in several vessels. It compares bypass surgery with stent treatment (PCI).
- Age
- 18 years or older
- Sex
- All sexes
- Disease stage
- Heart pump function (LVEF) of 40% or less. Narrowing in 2-3 coronary vessels, with a lesion above 70% including the proximal LAD, and/or left main stenosis above 50%. Chest pain (angina, CCS 2 or more) and/or a hospital stay for acute coronary syndrome or heart failure within the last year. The local Heart Team must judge that both bypass surgery and PCI are possible.
- Earlier treatment
- No previous bypass surgery (CABG).
Main reasons for not taking part
- Acute coronary syndrome less than 48 hours before randomization
- Heart valve or structural heart disease that needs an intervention
- Cannot take dual antiplatelet therapy (DAPT)
- Another illness with life expectancy under 1 year
- Heart failure that is decompensated at the time of joining
The registry criteria, word for word
Show all 12 criteriaShow less
Who can take part
- Age ≥ 18 years
- LVEF≤ 40%
- Angina pectoris, CCS≥2 and/or hospitalization for ACS or heart failure within 1 year prior to randomization
- Multivessel CAD (2-3 vessel-disease with coronary lesions >70% and involvement of proximal LAD, and/or LM stenosis of >50%). Target vessels are determined by the local Heart Time
- Clinical and angiographical characteristics suitable for isolated coronary revascularization both by CABG or PCI according to the judgment of the local Heart Team
- Written informed consent
Who cannot take part
- Previous CABG
- Valvular/structural heart disease requiring intervention
- Non-cardiac condition with life expectancy < 1 year
- ACS < 48 hours before randomization
- Contra-indications to DAPT
- Decompensated HF at the time of inclusion
Where in Netherlands
- University Medical Center GroningenGroningen, NetherlandsContact: Erik Lipsic, Dr.Taking people
About the trial
What the trial wants to find out
This randomized multicenter trial compares coronary artery bypass grafting (CABG) with percutaneous coronary intervention (PCI) in 358 patients with ischemic left ventricular dysfunction and multivessel coronary disease. The study evaluates differences in survival, major cardiovascular events, and quality of life over 4 years, and contributes to the international STICH 3.0 collaboration assessing long-term outcomes.
The 2 groups in the trial
- CABG (surgery)Treatment being tested
Patients randomized to CABG will receive CABG - aiming for full revascularization
Treatment: CABG
- PCI (percutaneous)Other group
Patients randomized to PCI will receive PCI - aiming for full revascularization
Treatment: PCI
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Surgical Versus Percutaneous Revascularization in Patients With Reduced Left Ventricular Function
- Plain-language title
- Comparing Bypass Surgery and Stent Procedures for Heart Disease With Weak Heart PumpingGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 12 November 2026.
- Record updated
- 12 May 2026