Comparing Bypass Surgery and Stent Procedures for Heart Disease With Weak Heart Pumping
Compares bypass surgery with stenting in adults with blocked heart arteries and reduced heart function.
Plain-language title generated from the registry record
Registry title: Surgical Versus Percutaneous Revascularization in Patients With Reduced Left Ventricular Function (STICH 3.0-NL)
Key facts
- Where
- Groningen, NetherlandsSee the site
Where in Netherlands
- University Medical Center GroningenGroningen, NetherlandsTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University Medical Center Groningen
- Trial code
- NCT07269366
- Record updated
- 12 May 2026
- Original description
This randomized multicenter trial compares coronary artery bypass grafting (CABG) with percutaneous coronary intervention (PCI) in 358 patients with ischemic left ventricular dysfunction and multivessel coronary disease. The study evaluates differences in survival, major cardiovascular events, and quality of life over 4 years, and contributes to the international STICH 3.0 collaboration assessing long-term outcomes.Read full original descriptionShow less
Surgical Versus Percutaneous Revascularization in Patients With Reduced Left Ventricular Function
This randomized multicenter trial compares coronary artery bypass grafting (CABG) with percutaneous coronary intervention (PCI) in 358 patients with ischemic left ventricular dysfunction and multivessel coronary disease. The study evaluates differences in survival, major cardiovascular events, and quality of life over 4 years, and contributes to the international STICH 3.0 collaboration assessing long-term outcomes.
Inclusion: Age ≥ 18 years; LVEF≤ 40%; Angina pectoris, CCS≥2 and/or hospitalization for ACS or heart failure within 1 year prior to randomization; Multivessel CAD (2-3 vessel-disease with coronary lesions >70% and involvement of proximal LAD, and/or LM stenosis of >50%). Target vessels are determined by the local Heart Time; Clinical and angiographical characteristics suitable for isolated coronary revascularization both by CABG or PCI according to the judgment of the local Heart Team; Written informed consent.
Exclusion: Previous CABG; Valvular/structural heart disease requiring intervention; Non-cardiac condition with life expectancy < 1 year; ACS < 48 hours before randomization; Contra-indications to DAPT; Decompensated HF at the time of inclusion.