Compares semaglutide injections with calorie reduction in type 2 diabetes
Tests semaglutide injections against calorie reduction in adults with type 2 diabetes and fatty liver.
Plain-language title generated from the registry record
Registry title: The Impact of Semaglutide Compared to Energy Restriction on Type 2 Diabetes
Key facts
- Where
- Jiangxi, ChinaSee the site
- Phase
- Phase 4
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with newly diagnosed type 2 diabetes and overweight. It compares semaglutide injections with eating less energy for 12 weeks.
- Age
- 18 to 75 years
- Sex
- All sexes can join.
- Disease stage
- Type 2 diabetes diagnosed 3 months ago or less, with HbA1c 8.5% (69 mmol/mol) or lower.
- Earlier treatment
- No use of diabetes drugs. No weight-loss drugs or attempts in the past 3 months. No GLP-1 receptor agonists, sodium-glucose cotransporter 2 inhibitors, dipeptidyl peptidase-4 inhibitors or thiazolidinediones in the past 3 months.
- Biomarker or test result
- BMI of 25 kg/m² or higher; HbA1c 8.5% (69 mmol/mol) or lower.
Main reasons for not taking part
- History of type 1 diabetes, acute pancreatitis or diabetes after pancreas removal
- History of bariatric surgery or planned bariatric surgery
- Pregnant, breastfeeding or planning pregnancy during the study
- Severe heart, lung, stomach and bowel, kidney, blood, nerve disease or cancer
- Personal or family history of medullary thyroid carcinoma
Read by machine on 9 November 2026.
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 75 years old?
Source: NCT07272343, who can take part
Where in China
- Minde road No.1Jiangxi, ChinaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Second Affiliated Hospital of Nanchang University
- Trial code
- NCT07272343
- Record updated
- 2 April 2026
- Original description
To evaluate the effects of subcutaneous injection of semaglutide for 12 weeks on patients with type 2 diabetes mellitus (T2DM), compared with concurrent energy-restricted management, on glycemic control, weight loss, inflammatory markers, liver fat content, and other parameters. The study also observed the subcutaneous and visceral fat of the participants and explored the molecular mechanisms of action, providing high-quality evidence-based support for the timing and targets of intervention in this population.Read full original descriptionShow less
A Study on the Impact of Semaglutide Compared to Energy Restriction on Type 2 Diabetes Combined With Metabolic-associated Fatty Liver Disease and Its Molecular Mechanisms
To evaluate the effects of subcutaneous injection of semaglutide for 12 weeks on patients with type 2 diabetes mellitus (T2DM), compared with concurrent energy-restricted management, on glycemic control, weight loss, inflammatory markers, liver fat content, and other parameters. The study also observed the subcutaneous and visceral fat of the participants and explored the molecular mechanisms of action, providing high-quality evidence-based support for the timing and targets of intervention in this population.
Inclusion: Age 18-75 years; BMI≥25 kg/m²; Diagnosed as type 2 diabetes mellitus patients according to the "Guidelines for the Prevention and Treatment of Type 2 Diabetes in China (2020 Edition)"; HbA1c≤8.5%; Duration of diabetes ≤3 months, and no use of antihyperglycemic drugs; Willing to participate in this study, and after full informed consent, agrees to strictly follow the treatment plan and promises to attend follow-up visits on time, and signs the informed consent form.
Exclusion: History of type 1 diabetes, acute pancreatitis, or diabetes secondary to pancreatectomy; History of bariatric surgery or planned bariatric surgery, or currently attempting weight loss within the past 3 months, or use of weight-loss medications within the past 3 months; Patients with severe diseases of important organ systems, such as severe cardiovascular and cerebrovascular diseases, respiratory diseases, gastrointestinal diseases, renal insufficiency, hematologic diseases, neurological diseases, or malignancies; Personal or family history of medullary thyroid carcinoma; Patients with severe mental disorders or communication barriers that prevent accurate understanding of the study content and compliance with the trial procedures; Use of GLP-1 receptor agonists, sodium-glucose cotransporter 2 inhibitors, dipeptidyl peptidase-4 inhibitors, thiazolidinediones, or other related drugs within the past 3 months; Age < 18 years, or > 75 years; BMI < 25 kg/m²; Pregnant or breastfeeding women, or those planning to conceive during the study period.