Comparing Two Operations for Thyroid Cancer Located in the Isthmus
Compares removing the isthmus alone with removing the whole thyroid in adults.
Plain-language title generated from the registry record
Registry title: Comparing the Therapeutic Efficacy of Extended Isthmusectomy Versus Total Thyroidectomy for Isthmus Tumors of the Thyroid
Key facts
- Where
- Hangzhou, ChinaSee the site
Where in China
- 2nd Affiliated Hospital, School of Medicine, Zhejiang University, ChinaHangzhou, ChinaNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Second Affiliated Hospital, Zhejiang University, School of Medicine
- Trial code
- NCT07274605
- Record updated
- 10 December 2025
- Original description
Prospective randomized open phase III non-inferiority trial in cT1bN0N1aM0 isthmus tumors of the thyroid comparing: extended Isthmusectomy (Isthmusectomy + Central Neck Dissection)(experimental group) versus total thyroidectomy + Central Neck Dissection (reference group).Read full original descriptionShow less
Comparing the Therapeutic Efficacy of Extended Isthmusectomy Versus Total Thyroidectomy for Isthmus Tumors of the Thyroid: A Prospective, Multicenter, Open-Label, Randomized Controlled Trial.
Prospective randomized open phase III non-inferiority trial in cT1bN0N1aM0 isthmus tumors of the thyroid comparing: extended Isthmusectomy (Isthmusectomy + Central Neck Dissection)(experimental group) versus total thyroidectomy + Central Neck Dissection (reference group).
Inclusion: Age 18 years or older; Diagnosis of low-risk differentiated thyroid cancer (papillary, follicular, or Hürthle cell carcinoma); Unifocal tumor located in the thyroid isthmus, cT1b; No evidence of extrathyroidal extension, assessed by preoperative ultrasound.
Exclusion: Aggressive pathological subtypes (e.g., tall cell, clear cell, columnar cell, or diffuse sclerosing variants of papillary thyroid carcinoma, as well as poorly differentiated types); cN1b; M1; Combined with other suspicious thyroid nodules within the lobes.