Dexmedetomidine plus fentanyl versus fentanyl alone in spinal anesthesia for leg amputation in sarcoma
Compares two spinal pain-relief drug mixes after above-knee amputation for leg sarcoma.
Plain-language title generated from the registry record
Registry title: Intrathecal Dexmedetomidine-Fentanyl Combination Versus Fentanyl Alone as Adjuvant to Bupivacaine in Spinal Anesthesia for Above Knee Amputation in Sarcomas of Lower Extremity
Key facts
- Where
- Cairo, EgyptSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 60 years old?
Source: NCT07276867, who can take part
Where in Egypt
- National Cancer InstituteCairo, EgyptTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- National Cancer Institute, Egypt
- Trial code
- NCT07276867
- Record updated
- 11 December 2025
- Original description
The current work evaluated whether the combination of intrathecal dexmedetomidine and fentanyl provides superior postoperative analgesia to fentanyl alone when administered with hyperbaric bupivacaine.Read full original descriptionShow less
Intrathecal Dexmedetomidine-Fentanyl Combination Versus Fentanyl Alone as Adjuvant to Bupivacaine in Spinal Anesthesia for Above Knee Amputation in Sarcomas of Lower Extremity: A Randomized, Comparative Study
The current work evaluated whether the combination of intrathecal dexmedetomidine and fentanyl provides superior postoperative analgesia to fentanyl alone when administered with hyperbaric bupivacaine.
Inclusion: Age from 18 to 60 years; Both sexes; American Society of Anesthesiologists (ASA) physical status of II-III; Height between 150-185 cm; Body mass index between 18-35 kg/m²; Scheduled for above-knee amputation due to lower limb sarcomas.
Exclusion: Allergy to any of the investigated drugs; Presence of psychiatric illness or chronic pain conditions; History of heart block, arrhythmia, or ongoing therapy with beta- or calcium channel- blockers, or angiotensin-converting-enzyme inhibitors; Contraindications to spinal anesthesia; Pregnancy or lactation.