Testing Focused Ultrasound to Support Recovery After Severe Brain Injury
Tests gentle focused ultrasound in adults with lasting impaired consciousness after severe brain injury.
Plain-language title generated from the registry record
Registry title: Promoting Recovery After Brain Injury Using Focused Ultrasound
Key facts
- Where
- Boston and Cambridge, United StatesSee the 2 sites
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 79 years old?
Source: NCT07277309, who can take part
Where in United States
- Massachusetts General Hospital (The General Hospital Corp.)Boston, United StatesTaking people
- Spaulding Rehabilitation Hospital Corporation, Inc.Cambridge, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Massachusetts General Hospital
- Trial code
- NCT07277309
- Record updated
- 15 June 2026
- Original description
The overall aim of this study is to develop an intervention that can help recovery in patients surviving severe brain injury but failing to fully recover. In particular, this project aims to (1) determine neurobehavioral responses to low-intensity focused ultrasound (LIFUP) in patients with disorders of consciousness (DoC) following brain injury, (2) determine neurophysiologic (EEG) responses to LIFUP in patients with DoC and (3) identify and evaluate ethical perspectives of patient representatives (family members and surrogate decision-makers) surrounding investigation of therapeutic neuromodulation technologies such as LIFUP in patients with DoC.Read full original descriptionShow less
Promoting Recovery After Brain Injury Using Focused Ultrasound
The overall aim of this study is to develop an intervention that can help recovery in patients surviving severe brain injury but failing to fully recover. In particular, this project aims to (1) determine neurobehavioral responses to low-intensity focused ultrasound (LIFUP) in patients with disorders of consciousness (DoC) following brain injury, (2) determine neurophysiologic (EEG) responses to LIFUP in patients with DoC and (3) identify and evaluate ethical perspectives of patient representatives (family members and surrogate decision-makers) surrounding investigation of therapeutic neuromodulation technologies such as LIFUP in patients with DoC.
Inclusion: Brain injury resulting in DoC diagnosis, following international guidelines; At least 18 years of age; Legally authorized representative (surrogate) available to consent.
Exclusion: Participation in concurrent therapeutic study; History of neurological disorder other than the brain injury; Metal implant or other condition precluding MRI; Manifest continuous spontaneous movement (which would prevent safe/successful MRI); Pregnancy.