A Decision Tool to Help Start HIV Prevention Medicine in Emergency Departments
Tests a decision tool for starting PrEP in emergency department patients at HIV risk.
Plain-language title generated from the registry record
Registry title: Decision Support Tool to Integrate PrEP Into Emergency Departments
Key facts
- Where
- Baltimore and Washington D.C., United StatesSee the 2 sites
- Phase
- Phase 1
Where in United States
- Johns Hopkins Hospital Emergency DepartmentBaltimore, United StatesNo longer taking part
- George Washington University Emergency DepartmentWashington D.C., United StatesNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- George Washington University
- Trial code
- NCT07279129
- Record updated
- 8 October 2026
- Original description
This project will explore the development of a personalized decision support tool to assist with pre-exposure prophylaxis (PrEP) initiation and persistence among patients identified in the emergency department (ED) and urgent care settings as PrEP eligible. First, the investigators will use a sequence of validated implementation science methodologies to develop and validate a decision support tool designed to optimize PrEP persistence by strengthening self-efficacy by addressing the multifaceted medical and social needs of the individual patient. The investigators will then test the preliminary effectiveness of this tool through a pilot stepped wedge implementation trial in two EDs and an urgent care in Baltimore, MD and Washington, DC among 120 PrEP eligible patients to determine PrEP initiation, linkage to care, persistence, and adherence rates.Read full original descriptionShow less
A Pilot Feasibility Study to Integrate PrEP Into Emergency Departments Using Decision Support Tools
This project will explore the development of a personalized decision support tool to assist with pre-exposure prophylaxis (PrEP) initiation and persistence among patients identified in the emergency department (ED) and urgent care settings as PrEP eligible. First, the investigators will use a sequence of validated implementation science methodologies to develop and validate a decision support tool designed to optimize PrEP persistence by strengthening self-efficacy by addressing the multifaceted medical and social needs of the individual patient. The investigators will then test the preliminary effectiveness of this tool through a pilot stepped wedge implementation trial in two EDs and an urgent care in Baltimore, MD and Washington, DC among 120 PrEP eligible patients to determine PrEP initiation, linkage to care, persistence, and adherence rates.
Inclusion: English-speaking; Self-report being HIV negative (GWU sites) or are found to be HIV rapid test negative (JHH ED); Medically stable ED/UC patients (defined as a triage category level 3, 4, 5 using Emergency Severity Index for ED patients only).
Exclusion: Currently taking PEP, PrEP, or present with signs/symptoms of acute HIV infection; Currently taking a nephrotoxic medication; Diagnosed with medical conditions that are contraindicated with use of TDF/FTC or TAF/FTC; Have a comorbid medical or psychiatric condition that would make PrEP adherence or ongoing follow-up care difficult; Pregnant; Admission to the hospital; Are in police custody/prisoner during the ED visit.