Tests AI help in reading low-dose CT scans for lung cancer
Tests AI-assisted reading of low-dose CT scans in people at risk of lung cancer.
Key facts
- Who runs it
- Taipei Veterans General Hospital, Taiwan
- Where
- Taipei, TaiwanSee the site
- Trial code
- Registry title
- Evaluation of AI-assisted LDCT Screening in Lung Cancer
- Status
- Not yet recruiting
- People taking part
- 1,120 people, planned
- Started
- 11 Dec 2025
- Expected to end
- 31 Dec 2031
- Type of study
- Interventional, 2 groupsOne group gets no study treatment, for comparison.
- Treatments tested
- AI-assisted Low-Dose CT Interpretation
- Record updated
- 12 December 2025
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults who attend lung cancer screening with a low-dose CT scan. It compares AI-assisted reading of the scan with standard reading.
- Age
- 40 to 74 years. The exact range depends on the entry route.
- Sex
- Men and women can join.
- Earlier treatment
- No chest CT or other higher-radiation chest imaging in the past 12 months. No lung cancer in the past three years.
Main reasons for not taking part
- Pregnant women
- Chest CT or higher-radiation chest imaging in the past 12 months
- Lung cancer in the past three years
- Coughing up blood of unknown cause in the past month
- Unexplained weight loss of more than 6 kg (13 lb) in the past year
The registry criteria, word for word
Show all 13 criteriaShow less
Who can take part
- Family History of Lung Cancer: Males aged 45-74 or females aged 40-74 with first-degree relatives (parents, siblings, or children) diagnosed with lung cancer
- Heavy Smoking History: Ages 50-74 with ≥20 pack-years smoking history, currently smoking or quit <15 years ago
- General Screening Participants: Adults aged 40 years or older attending routine health check-ups
Who cannot take part
- Chest CT or other higher-radiation chest imaging within the past 12 months
- Inability to undergo thoracic puncture or surgery
- Individuals holding a major illness certificate for lung cancer
- History of lung cancer within the past three years
- Presence of other severe diseases with an expected life expectancy <5 years
- Pregnant women
- Inability to hold breath or otherwise complete the scanning procedure
- Hemoptysis of unknown cause within the past month
- Chest X-ray within the past month showing suspicious lung lesions
- Unexplained weight loss >6 kg within the past year
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 40 and 74 years old?
Where in Taiwan
- Taipei Veterans General HospitalTaipei, TaiwanContact: Hao-Min Cheng, M.D., Ph.D.No longer taking part
About the trial
What the trial wants to find out
This multicenter pragmatic randomized controlled trial evaluates whether AI-assisted interpretation of low-dose CT (LDCT) improves lung cancer screening performance compared with standard reading. Eligible participants are randomized to AI-assisted or conventional interpretation. The study assesses diagnostic accuracy, efficiency, lung cancer incidence, mortality, recurrence, and smoking cessation outcomes. Results will inform the clinical utility and potential implementation of AI-assisted LDCT in routine screening practice.
The 2 groups in the trial
- AI-assisted LDCT InterpretationTreatment being tested
Treatment: AI-assisted Low-Dose CT Interpretation
- Standard Radiologist LDCT InterpretationNo study treatment, for comparison
Participants undergo low-dose computed tomography (LDCT) lung cancer screening. Images are interpreted solely by radiologists without AI assistance.
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Evaluation of AI Medical Software-assisted LDCT Interpretation in Lung Cancer Screening and Prognosis: a Randomized Controlled Trial
- Plain-language title
- Tests AI help in reading low-dose CT scans for lung cancerGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 12 November 2026.
- Fit questions
- Built from NCT07280559, who can take part
- Record updated
- 12 December 2025