Tests high-intensity exercise for language recovery after stroke
Tests a high-intensity exercise program in adults with aphasia after stroke.
Plain-language title generated from the registry record
Registry title: Aphasia Physical EXercise Study: Randomized Trial
Key facts
- Where
- Berkeley, Hayward, and San Francisco, United StatesSee the 4 sites
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 80 years old?
Source: NCT07281313, who can take part
Where in United States
- University of California, BerkeleyBerkeley, United StatesTaking people
- California State University, East BayHayward, United StatesTaking people
- University of California San FranciscoSan Francisco, United StatesTaking people
- University of San FranciscoSan Francisco, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of California, Berkeley
- Trial code
- NCT07281313
- Record updated
- 19 March 2026
- Original description
The goal of this clinical trial is to evaluate the effects of a high-intensity exercise program on recovery in individuals with post-stroke aphasia. The high-intensity exercise program has been specifically designed for individuals with post-stroke aphasia and includes an interval training full-body workout, which can increase cardiovascular fitness, improve muscle strength and motor performance, and maximize cognitive and language gains. The main question this study aims to answer is:Read full original descriptionShow less
High-intensity Exercise in Stroke Recovery: Randomized Trial
The goal of this clinical trial is to evaluate the effects of a high-intensity exercise program on recovery in individuals with post-stroke aphasia. The high-intensity exercise program has been specifically designed for individuals with post-stroke aphasia and includes an interval training full-body workout, which can increase cardiovascular fitness, improve muscle strength and motor performance, and maximize cognitive and language gains. The main question this study aims to answer is:
• Does participation in a high-intensity exercise program lead to changes in physical health, language, cognitive, motor recovery, psychological and/or psychosocial domains?
Participants will be randomly assigned to either a high-intensity exercise program (target intervention) or a low-intensity exercise program (control intervention) delivered over 12-weeks in a group setting.
Outcome measures will be collected once immediately after the intervention period and once during the following 12-week maintenance period to capture short- and long-term effects of the exercise program.
Inclusion: Aphasia following ischemic or hemorrhagic stroke; Aphasia as determined by a standardized language test (Western Aphasia Battery Aphasia Quotient < 93.8 at study intake); At least 6 months from the last stroke; Proficient in English before the stroke; At least 8 years of education; Between the ages of 18 and 80; Independent with ambulation without a device (single-point cane accepted); Medically stable with no contraindications to participate in regular physical exercise as determined by the patients' own primary care provider or other treating provider.
Exclusion: Prior history of dementia, neurologic illness (other than stroke), or recent (last 3 years) substance abuse; Self-report uncontrolled cardiorespiratory and/or metabolic disorders incompatible with exercise; Significant visual or hearing disabilities (e.g., neglect, uncorrected visual or hearing loss) that interfere with testing.