How digestion works after weight-loss surgery in people with obesity
Studies how the gut digests food in adults after bariatric surgery.
Plain-language title generated from the registry record
Registry title: Gastro-Intestinal Digestion and Physiology After Bariatric Surgery
Key facts
- Where
- Leuven, NetherlandsSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 65 years old?
Source: NCT07286968, who can take part
Where in Netherlands
- Universitaire Ziekenhuizen KU LeuvenLeuven, NetherlandsTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Universitaire Ziekenhuizen KU Leuven
- Trial code
- NCT07286968
- Record updated
- 20 January 2026
- Original description
The goal of this clinical trial is to characterize gastrointestinal digestion and physiology in patients after bariatric surgery, or people living with obesity. The main question it aims to answer is: what is the status of gastrointestinal digestion and physiology after bariatric surgery? Participants will have two study visits: 1) participants will undergo collection of gastrointestinal samples and 2) participants will ingest an ingestible capsule that measures multiple physiological parameters along the gastrointestinal tract.Read full original descriptionShow less
Gastro-Intestinal Digestion and Physiology After Bariatric Surgery
The goal of this clinical trial is to characterize gastrointestinal digestion and physiology in patients after bariatric surgery, or people living with obesity. The main question it aims to answer is: what is the status of gastrointestinal digestion and physiology after bariatric surgery? Participants will have two study visits: 1) participants will undergo collection of gastrointestinal samples and 2) participants will ingest an ingestible capsule that measures multiple physiological parameters along the gastrointestinal tract.
Inclusion: Participants eligible for inclusion in this Investigation have to meet all of the following criteria:; Voluntary written informed consent of the participant has been obtained prior to any screening procedures; Age: 18-65 years; Specific inclusion criteria for the different patient populations:; Patients with obesity:; Body Mass Index: > 30 kg/m2; Patients after bariatric surgery:; Surgery: at least one year after Roux-en-Y gastric bypass or sleeve gastrectomy.
Exclusion: Patient had gastrointestinal surgery in the past three months; Patient is planned to undergo usage of rectal foam/enema or treatment with adjuvant chemotherapy or radiotherapy; Patient is currently on parenteral diet; Patient cannot discontinue medication that affects gastrointestinal transit time and/or pH for at least 3 days before and during the study (and 4 weeks for weekly/long-acting GLP-1 analogues such as Saxenda, Ozempic, Wegovy, Mounjaro). This includes opioids (e.g., morphine, codeine), proton pump inhibitors (e.g., omeprazole, esomeprazole, pantoprazole), H2-receptor antagonists (e.g., cimetidine, famotidine), antacids, sucralfate, prokinetics (e.g., domperidone, metoclopramide), antidiarrheal agents (e.g., loperamide), antibiotics, probiotics and prebiotics; Patient has history of more than one bariatric surgery; Patient has swallowing disorders, among others: dysphagia for food or pills, any oropharyngeal or oesophageal stricture, anxiety or functional abnormality; Patient has Crohn's disease or Diverticulitis; Patient has a history of complex bowel resection or known abdominal adhesions; Patient has short bowel syndrome or ostomy; Patient has currently ongoing infections; Any disorder, which in the investigator's opinion might jeopardise participant's safety or compliance with the CIP; Participants eligible for this Investigation must not meet any of the following criteria:; Patient has a waist circumference > 125.6 cm; Patient has a pacemaker, defibrillator, infusion pump, or other portable or implanted electromedical device; Patient had frequent exposure to X-rays in the past year; Patient has gastrointestinal strictures, fistulas or physiological/mechanical obstructions; Patient has gastric bezoar; Patient is planned to undergo MRI procedure during usage of the wireless capsule; Patient is working in a professional healthcare facility (e.g. hospital, dental office, emergency room), military area (e.g. submarine, near radar installation), or heavy industrial area (e.g. power plants, automotive, mining, refineries) during the duration of the clinical investigation; Patient is pregnant, breastfeeding, actively trying to get pregnant or had recent childbirth in last 6 months.