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Testing an automatic insulin pump in adults with diabetes and slow stomach emptying

Tests an automatic insulin pump in adults with type 1 diabetes and slow stomach emptying.

Key facts

Who runs it
Viral N. Shah
Where
Indianapolis, United StatesSee the site
Trial code
Registry title
To Study the Efficacy and Safety of Medtronic 780G Insulin Pump in People With Gastroparesis and Type 1 Diabetes.
Status
Recruiting
People taking part
34 people, planned
Started
9 Feb 2026
Expected to end
1 Apr 2027
Type of study
Interventional, 2 groupsOne group gets no study treatment, for comparison.
Treatments tested
  • Medtronic 780G AID
Record updated
10 November 2026

Who can take part

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for adults with type 1 diabetes and gastroparesis (slow stomach emptying) to test the Medtronic 780G automated insulin pump.

Age
18 years or older
Sex
All sexes can join
Disease stage
Type 1 diabetes for at least 12 months, with a stable insulin plan for at least 2 months. HbA1c of 8.0% (64 mmol/mol) or higher. Gastroparesis diagnosed by the National Institute of Health (NIH) definition.
Earlier treatment
Must have a stable insulin plan for at least 2 months. Must be willing to use the Medtronic 780G system with the Simplera CGM. If in the usual care group and already on a pump, must use it in manual mode only.
Biomarker or test result
HbA1c of 8.0% (64 mmol/mol) or higher

Main reasons for not taking part

  • Pregnancy, breastfeeding, or wanting to become pregnant
  • Using inhaled insulin (Afrezza) or any glucose-lowering medicine other than insulin
  • Kidney function eGFR below 30, or on dialysis
  • Severe low blood sugar in the past 3 months, or 2 or more hospital stays for DKA in the past 12 months
  • Steroid medicine for 2 weeks or more, or history of stomach outlet blockage or other structural stomach and gut problems

The registry criteria, word for word

Show all 19 criteriaShow less

Who can take part

  • Age ≥18 years
  • Diagnosis of T1D for at least 12 months with stable insulin regimen for at least 2 months
  • HbA1c ≥8.0%
  • Diagnosis of gastroparesis per National Institute of Health (NIH) definition
  • Willing to use Medtronic 780G system either with Simplera CGM
  • Ability to provide informed consent before any trial-related activities
  • If randomized to usual care group and on an insulin pump already, should be willing to use pump in manual mode only for the duration of the study

Who cannot take part

  • Current use (≥ 2 weeks of continuous use) of any steroidal medication, or anticipated long-term steroidal treatment (>4 weeks continuously), during the study period
  • History of SH in the previous 3 months
  • Use of investigational drugs within 5 half-lives prior to screening
  • History of gastric outlet obstruction or other gastrointestinal structural abnormalities
  • History of two or more episodes DKA requiring hospitalization in the past 12 months
  • Any medical (such as severe cardiovascular disease, malignancy, chronic liver disease) or psychosocial conditions that make a person unfit for the study at the discretion of investigators
  • Current use of cannabis or history of cannabinoid hyperemesis syndrome
  • Patients with T1D using any glucose lowering medications other than insulin at the time of screening
  • Estimated glomerular filtration rate (eGFR) <30 or on dialysis
  • Age <18 years
  • Current use of inhaled insulin (Afrezza)
  • Pregnancy, breast feeding, or wanting to become pregnant

Where in United States

  • Indiana University Health, Univeristy hospitalIndianapolis, United StatesContact: Zunera Tariq, MDTaking people

About the trial

What the trial wants to find out

The goal of this clinical trial is to evaluate the efficacy and safety of Medtronic 780G automated insulin delivery system in adult persons with type 1 diabetes and gastroparesis.

The 2 groups in the trial

  • Medtronic 780G groupTreatment being tested

    Treatment: Medtronic 780G AID

  • Usual careNo study treatment, for comparison

    Participants will continue either multiple daily injections or non-AID insulin pumps

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
Efficacy and Safety of Medtronic 780G Automated Insulin Delivery System in Adults With Type 1 Diabetes and Gastroparesis
Plain-language title
Testing an automatic insulin pump in adults with diabetes and slow stomach emptyingGenerated from the registry record. The registry title is the official one.
AI summary
From the trial's eligibility criteria. Read by machine on 12 November 2026.
Record updated
10 November 2026