Tests vagus nerve stimulation with walking training after stroke
Tests nerve stimulation plus walking exercises for adults with long-term stroke effects.
Plain-language title generated from the registry record
Registry title: A Study Of Vagus Nerve Stimulation (VNS) With Mobility Training For Gait Recovery After Chronic Ischemic Stroke
Key facts
- Where
- Rochester, United StatesSee the site
Where in United States
- Mayo Clinic in RochesterRochester, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Mayo Clinic
- Trial code
- NCT07291024
- Record updated
- 17 February 2026
- Original description
The purpose of this study is to evaluate the safety, feasibility, and efficacy of vagus nerve stimulation (VNS) paired with mobility training to improve lower extremity function and gait in individuals with chronic ischemic stroke.Read full original descriptionShow less
Vagus Nerve Stimulation (VNS) Paired With Mobility Training For Gait Recovery After Chronic Ischemic Stroke With Integration Of Biomarker Assessment
The purpose of this study is to evaluate the safety, feasibility, and efficacy of vagus nerve stimulation (VNS) paired with mobility training to improve lower extremity function and gait in individuals with chronic ischemic stroke.
Inclusion: Age ≥ 18 years; Ischemic stroke ≥6 months prior to enrollment; Post-stroke lower extremity impairment defined as gait velocity of less than 0.8 m/s on a 10-meter walk test; Provision of informed consent.
Exclusion: Active or prior psychosis or substance abuse within two years; Intracerebral Hemorrhage; Pre-stroke modified Rankin Scale (mRS) 3-5; Preexisting neurological disorders affecting gait and mobility, such as Parkinson's disease, Amyotrophic Lateral Sclerosis (ALS), Multiple Sclerosis (MS), dementia, major head trauma; Unable to participate in in-clinic rehabilitation.