Comparing MRI and Ultrasound to Find Liver Cancer in People With Cirrhosis
Compares ultrasound and abbreviated MRI for spotting liver cancer in adults with cirrhosis.
Key facts
- Who runs it
- Mattias Ekstedt
- Where
- Linköping, SwedenSee the site
- Trial code
- Registry title
- A Comparative Study of MRI and Ultrasound for Detection of Primary Hepatocellular Carcinoma, Body Composition and Risk Factors for Decompensation in Liver Cirrhosis
- Status
- Recruiting
- People taking part
- 600 people, planned
- Started
- 18 Dec 2025
- Expected to end
- Dec 2031
- Type of study
- Observational
- Record updated
- 19 December 2025
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with liver cirrhosis who have not had liver cancer. It compares ultrasound and a short MRI scan for finding liver cancer early.
- Age
- 18 to 84 years
- Sex
- All sexes can join.
- Disease stage
- Liver cirrhosis, as found in clinical practice by elastography, symptoms, biopsy, or radiology.
- Earlier treatment
- People who had a liver transplant cannot join.
Main reasons for not taking part
- Cannot have an MRI (for example iron-containing material in the body, or claustrophobia)
- Pregnancy
- Primary sclerosing cholangitis (PSC)
- Vascular liver disease or congenital liver fibrosis
- Earlier diagnosis of liver cancer (HCC)
The registry criteria, word for word
Show all 10 criteriaShow less
Who can take part
- Patients with liver cirrhosis, according to clinical practice. Based on criteria such as elastography, symptoms, biopsy, or radiology
- Age ≥18 years ≤ 84
- Written informed consent from the participant
Who cannot take part
- Previous diagnosis of hepatic carcinoma (HCC)
- Previous liver transplant
- Vascular liver disease
- Contraindications for MRI (ferrrous material, claustrophobia)
- Pregnancy
- Diagnosis of primary sclerosing cholangitis (PSC)
- Congenital liver fibrosis
Where in Sweden
- Department of gastroenterology and hepatology, University hospital in LinköpingLinköping, SwedenContact: Mattias Ekstedt, MD, PhDTaking people
About the trial
What the trial wants to find out
DETECT-HCC-ESLD is a prospective multicenter study designed to examine early detection and risk stratification of hepatocellular carcinoma (HCC) in individuals with advanced liver disease. Adults with cirrhosis of different etiologies are enrolled and followed longitudinally with structured clinical assessments and imaging at predefined intervals.
Read full original descriptionShow less
A key objective is to evaluate ultrasound and abbreviated MRI (AMRI) as surveillance modalities for HCC. The study examines detection performance, feasibility, and factors influencing image quality and interpretability.
The protocol also includes the study of body composition, focusing on how variations in adiposity and muscle mass may relate to imaging characteristics, disease progression, and HCC risk.
Longitudinal clinical and imaging data are used to explore prediction models aimed at identifying patients with differing levels of HCC risk. The study records outcomes such as incident HCC, liver-related complications, and mortality to support analyses of disease trajectories.
The DETECT-HCC-ESLD study provides a structured framework for collecting clinical, imaging, and body composition data over time, enabling detailed evaluation of surveillance strategies and risk patterns in advanced liver disease.
The group in the trial
- Adult patients with liver cirrhosis without prior hepatocellular carcinoma
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- A Comparative Study of MRI and Ultrasound for Detection of Primary Hepatocellular Carcinoma, Body Composition and Risk Factors for Decompensation in Liver Cirrhosis
- Plain-language title
- Comparing MRI and Ultrasound to Find Liver Cancer in People With CirrhosisGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 12 November 2026.
- Record updated
- 19 December 2025