How the Immune System's Complement Proteins Affect Kidney Disease in Diabetes
Studies how complement proteins relate to kidney damage in people with diabetes.
Plain-language title generated from the registry record
Registry title: Immune System in Diabetic Kidney Disease
Key facts
- Where
- Ljubljana, SloveniaSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 40 and 65 years old?
Source: NCT07292493, who can take part
Where in Slovenia
- University Medical Centre LjubljanaLjubljana, SloveniaNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University Medical Centre Ljubljana
- Trial code
- NCT07292493
- Record updated
- 23 February 2026
- Original description
Diabetes is a chronic condition marked by long-term elevated blood glucose levels. There are more types of diabetes; the majority of patients have type 1 or type 2 diabetes. Over long period of time, high blood sugar damages blood vessels and organs. One of the most common complications is diabetic kidney disease, which can slowly lead to kidney failure. People with this condition also have a much higher risk of heart and blood vessel diseases.Read full original descriptionShow less
The Role of Complement in Diabetic Kidney Disease
Diabetes is a chronic condition marked by long-term elevated blood glucose levels. There are more types of diabetes; the majority of patients have type 1 or type 2 diabetes. Over long period of time, high blood sugar damages blood vessels and organs. One of the most common complications is diabetic kidney disease, which can slowly lead to kidney failure. People with this condition also have a much higher risk of heart and blood vessel diseases.
Newer research shows that the immune system, especially the complement system (a group of proteins that help defend the body), may also play a role in worsening kidney disease in diabetes. High blood sugar can activate these proteins, and they have been found in kidney tissue of patients with diabetic kidney disease.
The goal of this study is to find out how much the complement system contributes to kidney damage in diabetes, whether it affects different groups of patients differently, and whether it is linked to blood vessel health or the stage of kidney disease. The study will also assess if improved diabetes control is linked to reduced complement system activity.
Inclusion: body mass index below 30 kg/m²; unknown macrovascular complications; treated with angiotensin-converting enzyme inhibitors or angiotensin receptor blockers at the highest tolerated dose.
Exclusion: a body mass index above 30 kg/m²; macrovascular complications.