Spastic Myopathy in Adults With Cerebral Palsy
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- Who runs it
- Neuroloco
- Trial code
- NCT07293988
- Record updated
- 19 December 2025
- Original description
Cerebral palsy (CP) is indeed the result of a central neurological lesion, but it also involves a lesser-known muscular condition that we refer to as spastic myopathy. This condition is likely the consequence of relative immobilization and underuse of the muscles in the affected limbs and, through a vicious cycle, it in turn plays a major role in movement difficulties. Among the muscles involved are the plantar flexors, whose extensibility decreases from the earliest years of the child's life.Read full original descriptionShow less
Clinical, Biomechanical, Histo-immunological and Radiological Characterization of the Effects of Two Gastrocnemius Stretching Programs in Adult Patients With Spastic Paresis Following Cerebral Palsy: MYOSPAS-CP, a Randomized Controlled Study
Cerebral palsy (CP) is indeed the result of a central neurological lesion, but it also involves a lesser-known muscular condition that we refer to as spastic myopathy. This condition is likely the consequence of relative immobilization and underuse of the muscles in the affected limbs and, through a vicious cycle, it in turn plays a major role in movement difficulties. Among the muscles involved are the plantar flexors, whose extensibility decreases from the earliest years of the child's life.
The BIOTN research team (UR7377; Université Paris-Est Créteil; Dr M. Pradines, Prof. J.-M. Gracies, CHU Henri Mondor, Créteil), supported by the Fondation pour la Paralysie Cérébrale, is conducting a randomized controlled study aimed, on the one hand, at characterizing in these individuals the genetic, histological, radiological, mechanical, physiological, and clinical changes in the calf muscle, and on the other hand, at exploring the reversibility of these alterations by comparing the effects of two types of rehabilitation after one year.
This study will provide essential insights for the development of specific and adapted rehabilitation strategies designed to improve the living conditions of individuals with cerebral palsy.
Inclusion: Hemiparesis or diparesis resulting from a cerebral lesion occurring during the perinatal period (cerebral palsy); Gastrocnemius extensibility XV1 < 100° (XV1, Tardieu Scale); Maximum barefoot walking speed (AT10) between 0.3 and 1.2 m/s; Written informed consent to participate in the study.
Exclusion: Botulinum toxin injections in the medial gastrocnemius within less than 3 months prior to study inclusion; Cognitive impairment preventing participation in the GSC program or in the study; Known hemostasis disorders; Hypersensitivity to allergens; Presence of a metallic intraocular foreign body (accidental fragments or others), a pacemaker, a neurostimulator (pain treatment), a cochlear implant, or, more generally, any implanted electronic medical device that cannot be removed; presence of a metallic cardiac valve in the study participant; Patients under legal guardianship or conservatorship.