Menthol gloves and socks for movement and sleep problems in Parkinson's disease
Tests menthol gloves and socks against placebo in people with Parkinson's disease.
Plain-language title generated from the registry record
Registry title: Menthol for Improving Movement and Sleep in Parkinson's Disease Patients
Key facts
- Where
- Taipei, TaiwanSee the site
- Phase
- Phase 2
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 30 and 80 years old?
Source: NCT07294469, who can take part
Where in Taiwan
- Taipei Medical University HospitalTaipei, TaiwanNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Taipei Medical University Hospital
- Trial code
- NCT07294469
- Record updated
- 8 January 2026
- Original description
Parkinson's disease (PD) is a progressive neurological disorder characterized by both motor and non-motor symptoms due to the degeneration of dopamine-producing neurons. There is currently no cure. Menthol, a natural compound that activates TRPM8 receptors, has shown neuroprotective and motor function benefits in preclinical PD models. In mice, distal limb immersion in menthol improved dopamine neuron survival and motor performance. Similar menthol-based interventions improved outcomes in a stroke model and a clinical trial with stroke patients. This study investigates whether topical menthol can offer therapeutic benefits for individuals with PD.Read full original descriptionShow less
Effect of Menthol on Motor Deficits and Sleep Disturbances in Patients With Parkinson's Disease
Parkinson's disease (PD) is a progressive neurological disorder characterized by both motor and non-motor symptoms due to the degeneration of dopamine-producing neurons. There is currently no cure. Menthol, a natural compound that activates TRPM8 receptors, has shown neuroprotective and motor function benefits in preclinical PD models. In mice, distal limb immersion in menthol improved dopamine neuron survival and motor performance. Similar menthol-based interventions improved outcomes in a stroke model and a clinical trial with stroke patients. This study investigates whether topical menthol can offer therapeutic benefits for individuals with PD.
Inclusion: aged between 30 and 80 years (inclusive); diagnosed with idiopathic PD based on the Brain Bank criteria of the UK Parkinson's Disease Society less than 3 years; Hoehn and Yahr stages 1-3 and currently receiving treatment; experiencing sleep disorders with a Pittsburgh Sleep Quality Index (PSQI) > 5; has signed the informed consent form approved by the Institutional Review Board and dated accordingly; no changes in PD medications within four weeks prior to participating in this trial, and no dosage changes during the study period; able to use other medications that may affect sleep, except those explicitly prohibited, provided the dosage has been stable for the four weeks before screening and remains unchanged during the study.
Exclusion: menthol allergy; patients with conditions such as uremia, cirrhosis, congestive heart failure with pulmonary edema, coagulation disorders, epilepsy, alcoholism, drug abuse, or; pregnant and breastfeeding women; diagnosed with secondary and atypical PD; deemed unsuitable for participation in this study by the principal investigator.