Vitamin D levels and blood molecular patterns in people with primary osteoporosis
Studies how vitamin D relates to blood markers in adults newly diagnosed with osteoporosis.
Plain-language title generated from the registry record
Registry title: Vitamin D Status and Multi-Omics Profiles in Primary Osteoporosis
Key facts
- Where
- Yichang, ChinaSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults newly diagnosed with primary osteoporosis, and also adults with normal bone density as healthy controls.
- Age
- 18 years or older
- Sex
- All sexes can join
- Disease stage
- Newly diagnosed primary osteoporosis (T-score of -2.5 SD or lower on a DXA bone scan), without serious complications that may affect the results. Healthy controls need normal bone density on DXA.
- Earlier treatment
- No vitamin D supplements, anti-osteoporosis drugs, glucocorticoids or other drugs affecting vitamin D or bone metabolism in the 3 months before joining.
Main reasons for not taking part
- Secondary osteoporosis, for example from hyperparathyroidism, tumors, chronic kidney disease, liver cirrhosis or rheumatoid arthritis
- Pregnant or breastfeeding women, or a mental disorder that prevents taking part in the study
- Acute infection, cancer, or severe liver, kidney, heart or brain blood vessel disease
- Blood transfusion in the month before joining, or unable to give a blood sample
Read by machine on 9 November 2026.
Where in China
- Yichang Second People's HospitalYichang, ChinaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Dr. Li Chen
- Trial code
- NCT07296471
- Record updated
- 22 December 2025
- Original description
This observational study aims to explore the relationships between vitamin D status and genomic, proteomic, and metabolomic profiles in patients with primary osteoporosis.Read full original descriptionShow less
An Observational Study to Explore the Associations Between Vitamin D Status and Genomic, Proteomic, and Metabolomic Profiles in Patients With Primary Osteoporosis
This observational study aims to explore the relationships between vitamin D status and genomic, proteomic, and metabolomic profiles in patients with primary osteoporosis.
Eligible participants are adults who are newly diagnosed with primary osteoporosis at Yichang Second People's Hospital. Blood samples will be collected at the initial diagnosis to analyze gene expression, protein levels, and metabolic profiles.
Participants will receive standard clinical treatment according to routine care, but no additional research sampling or follow-up will be performed.
The study seeks to identify molecular patterns associated with osteoporosis and improve understanding of patient responses to therapy.
Inclusion: Healthy controls: Adults aged ≥18 years, with normal bone mineral density (BMD) confirmed by dual-energy X-ray absorptiometry (DXA), without a history of bone metabolic diseases, major organ dysfunction, or chronic inflammatory/autoimmune diseases; Osteoporotic patients: Adults aged ≥18 years, newly diagnosed with primary osteoporosis according to clinical criteria (T-score ≤ -2.5 SD by DXA), without serious complications that may affect study results; Participants willing and able to provide written informed consent and cooperate with study procedures, including blood and serum sample collection and clinical data recording.
Exclusion: Individuals who have taken vitamin D supplements, anti-osteoporotic drugs, glucocorticoids, or other medications affecting vitamin D or bone metabolism within 3 months prior to enrollment; Participants with a history of blood transfusion within 1 month prior to enrollment or those unable to provide peripheral blood samples as required; Patients with secondary osteoporosis, including but not limited to osteoporosis caused by hyperparathyroidism, tumors, chronic kidney disease, liver cirrhosis, rheumatoid arthritis, or other autoimmune diseases; Pregnant or lactating women, or individuals with mental disorders preventing cooperation with study procedures; Individuals with acute infections, malignant tumors, or severe liver, kidney, cardiovascular, or cerebrovascular diseases that may affect study outcomes.