Brain Water Uptake on CT and Recovery After Clot-Dissolving Treatment for Stroke
Looks back at whether brain water uptake on CT relates to recovery after thrombolysis.
Plain-language title generated from the registry record
Registry title: Quantitative Net Water Uptake as a Predictor of Functional Outcomes After Intravenous Thrombolysis in Acute Ischemic Stroke International Multicenter Observational Retrospective Study
Key facts
- Where
- Vienna, AustriaSee the site
Where in Austria
- Department of Neurology, St. John's Hospital, Vienna, Austria, Vienna, 1020Vienna, AustriaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Sigmund Freud PrivatUniversitat
- Trial code
- NCT07299981
- Record updated
- 16 July 2026
- Original description
While the effectiveness of intravenous thrombolysis (IVT) decreases over time, patients show considerable variability in how quickly their ischemic core progresses. Quantitative net water uptake (NWU) has emerged as a biomarker indicating blood-brain barrier disruption and may better reflect the "tissue clock" than time alone. Low NWU is associated with favorable outcomes, whereas high NWU predicts poor outcomes and futile recanalization. The study aims to determine whether NWU measured on initial non-contrast CT is a treatment effect modifier for the IVT therapy.Read full original descriptionShow less
Quantitative Net Water Uptake as a Predictor of Functional Outcomes After Intravenous Thrombolysis in Acute Ischemic Stroke International Multicenter Observational Retrospective Study
While the effectiveness of intravenous thrombolysis (IVT) decreases over time, patients show considerable variability in how quickly their ischemic core progresses. Quantitative net water uptake (NWU) has emerged as a biomarker indicating blood-brain barrier disruption and may better reflect the "tissue clock" than time alone. Low NWU is associated with favorable outcomes, whereas high NWU predicts poor outcomes and futile recanalization. The study aims to determine whether NWU measured on initial non-contrast CT is a treatment effect modifier for the IVT therapy.
Inclusion: Acute ischemic stroke treated with intravenous thrombolysis; Imaging with non-contrast cranial CT on admission; Follow-up imaging with non-contrast cranial CT or MRI 12-24 hours after IVT; Final Infarct volume > 5ml; ASPECTS available.
Exclusion: Known use of oral anticoagulation (OAC) on admission; Preexisting ischemic infarction on admission non-contrast cranial CT; Patients with large vessel occlusion AIS who underwent mechanical thrombectomy; Low imaging quality precluding radiological measurements; Severe white matter lesions precluding radiological measurements; No ASPECTS.