Acute Effects of Blood Flow Restriction Training to Failure on Hypoalgesia in Patients With Severe Knee Osteoarthritis Using Dynamic or Fixed Occlusion Pressure
Key facts
- Where
- Valencia, SpainSee the 2 sites
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 50 and 85 years old?
Source: NCT07300384, who can take part
Where in Spain
- Faculty of Physiotherapy. University of ValenciaValencia, SpainContact: Adrian Escriche-Escuder, PhDTaking people
- University of ValenciaValencia, SpainContact: Adrián Escriche-Escuder, PhDTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- University of Valencia
- Trial code
- NCT07300384
- Record updated
- 10 June 2026
- Original description
This study aims to compare the acute effects on hypoalgesia of training to failure using blood flow restriction (BFR) with dynamic occlusion versus BFR with fixed occlusion in patients with severe gonarthrosis. Two different training conditions will be performed with varying levels of blood flow occlusion (%BFR) and percentage of load (%RM): 1) 30% RM and 50% BFR with dynamic pressure; 2) 30% RM and 50% BFR with fixed pressure. Each participant will complete two individual sessions under different training conditions, randomly assigned with a 72-hour interval between sessions.Read full original descriptionShow less
This study aims to compare the acute effects on hypoalgesia of training to failure using blood flow restriction (BFR) with dynamic occlusion versus BFR with fixed occlusion in patients with severe gonarthrosis. Two different training conditions will be performed with varying levels of blood flow occlusion (%BFR) and percentage of load (%RM): 1) 30% RM and 50% BFR with dynamic pressure; 2) 30% RM and 50% BFR with fixed pressure. Each participant will complete two individual sessions under different training conditions, randomly assigned with a 72-hour interval between sessions.
Inclusion: Age between 50 and 85 years; Diagnosis of severe gonarthrosis according to the clinical and radiographic criteria of the American College of Rheumatology guidelines; On the waiting list for unilateral total knee replacement (TKR) surgery.
Exclusion: Previous hip or knee replacement surgery and osteotomy within the last year; Participation in exercise programs (>2 days/week with training at intensities of 10-15 1RM) in the previous six months; Autoimmune arthritis; Medical conditions that contraindicate exercise; History of stroke, brain surgery, major depression, or self-reported cognitive impairment that could affect performance in the study; Cardiovascular, thrombotic, or vascular risk factors (uncontrolled hypertension, peripheral arterial disease, history of deep vein thrombosis or pulmonary embolism, heart failure, severe varicose veins, or uncontrolled anticoagulant therapy); Skin or local alterations at the cuff application site (ulcers, open wounds, infections, lymphedema, or severe edema); Pain in the contralateral leg with an intensity ≥80/100 mm on the visual analog scale (VAS) during daily activities; Inability to communicate normally or with impaired communication skills.