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Pilot Study of Negative Pressure Neck Therapy (NPNT)

Key facts

Who runs it
University of British Columbia
Where
Canada2 sites in 1 countryChoose a country to see its sites
Trial code
Status
Not yet recruiting
People taking part
10 people, planned
Started
Jan 2026
Expected to end
Dec 2026
Type of study
Interventional, 2 groups
Treatments tested
  • Negative Pressure Neck Therapy (NPNT)
Record updated
24 December 2025

Who can take part

Age
19 years and older
Sex
Women and men
Healthy volunteers
Can take part

The registry criteria, word for word

Show all 14 criteriaShow less

Who can take part

  • Body mass index ≤42 kg/m2
  • Able to speak, read, and write English

Who cannot take part

  • No previous surgery, injury, or radiation to the neck
  • Use of illicit drugs currently or within the past 5 years
  • Previous surgery for peripheral arterial disease
  • Known sleep disorder such as Obstructive Sleep Apnea (OSA), narcolepsy, restless leg syndrome, idiopathic hypersomnolence or chronic insomnia
  • Inflammatory skin condition, such as acne or eczema in the neck area
  • Known silicone allergy
  • Serious pulmonary disease
  • Cancer that has been in remission for less than one year
  • Excessive hair or beard in the area of the neck, and/or unwillingness to shave that area for the duration of this study
  • Night shift work because of irregular sleep-wake cycles
  • Excessive alcohol intake, defined as that leading to interference with work, home life, or the ability to optimally perform normal everyday duties and tasks
  • Use of home oxygen or oxygen saturation <94%

This trial has no sites in United States.

It has sites in one country. Choose a country to see its sites.

About the trial

What the trial wants to find out

Obstructive sleep apnea (OSA) is a serious, chronic sleep-related breathing disease in which the upper airway repeatedly collapses during sleep, leading to intermittent oxygen deprivation. This pilot study will evaluate the Safety and Efficacy of Negative Pressure Neck Therapy (NPNT) in up to 10 healthy participants. Participants will undergo 2 separate home sleep apnea tests (HSAT) approximately 1 week apart and will be randomly assigned to wear the NPNT device at either night 1 or night 2 of HSAT. Participation will include 5 on-site visits and 1 phone call over approximately 1 month.

The 2 groups in the trial

  • Group 1Treatment being tested

    One night of Home sleep apnea testing (HSAT) with Negative Pressure Neck Therapy (NPNT) intervention, followed by 7 night washout, then one night of HSAT only

    Treatment: Negative Pressure Neck Therapy (NPNT)

  • Group 2Treatment being tested

    One night of HSAT only, followed by 7 night washout, then one night of HSAT with NPNT intervention.

    Treatment: Negative Pressure Neck Therapy (NPNT)

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
A Proof-of-concept Pilot Study to Determine the Safety and Effectiveness of the Negative Pressure Neck Therapy (NPNT) in Healthy Participants.
Record updated
24 December 2025