New PET scans to help detect kidney cancer (renal cell carcinoma)

Who can take part

• Tumor subjects:
• The subject or his/her legal representative is able to sign the informed consent form signed and dated
• Promise to abide by the research procedures and cooperate with the implementation of the whole process of research
• Adult subjects (aged 18 years or above), male or female
• Patients with clinically suspected or confirmed renal cell carcinoma (supporting evidence includes serum-related tumor markers, ultrasound, CT, MRI and other imaging data and histopathological examinations, etc.), and are in good general condition
• Conform to specific laboratory test results
• Contraception for at least one month before screening for females in the childbearing period, and commitment to use contraception throughout the study period and continue until the specified time after the end of the study
• Other set selection criteria; Healthy Subjects:
• Fully understand and voluntarily sign the informed consent form
• Male or female, age 18-70 years old
• Male weight >=50.0kg, female weight >=45.0kg; Body mass index (BMI) within the range of 19.0~26.0kg/m\^2 (including the cut-off value)
• No history of chronic or serious diseases such as cardiovascular, liver, kidney, respiratory, blood and lymphatic, endocrine, immunologic, psychiatric, neuromuscular, gastrointestinal system, etc., within three years, and in good general health
• There is no abnormality in vital signs examination and physical examination
• Have no fertility plan during the trial and within 6 months after the end of the trial and voluntarily take effective contraceptive measures and have no sperm and egg donation plans
• Able to communicate well with the investigator, and understand and comply with the requirements of the study

Who cannot take part

• Any serious or unstable medical condition; Those who have acute illness before the study; Previous or existing malignancy
• Those who have undergone surgery within 6 months before the trial, which is judged by the investigator to affect absorption, distribution, metabolism, and excretion
• Those who have used any drugs (including prescription drugs, over-the-counter drugs, and Chinese herbal medicines) within 2 weeks before the trial
• Patients with known hypersensitivity to targeted PSMA, CAIX or CD70 PET imaging agents or synthetic excipients; The fasting blood glucose level before injection of [18F]FDG exceeded 11.0 mmol/L
• Tumor subjects:
• Those who are unable to complete PET/MR or PET/CT examination (including inability to lie flat, claustrophobia, radiophobia, etc.)
• Patients who are pregnant or lactating
• Those who have other factors that are not suitable for participating in this test; Healthy Subjects:
• Pregnant and lactating women
• Participation in other research studies involving radioactive materials (within the past 12 months)
• Any other factors that affect the results of the study