Efficacy of Semaglutide s.c. Once-weekly on Weight Loss and Management in Adolescents With Monogenic Obesity in Clinical Practice
Key facts
- Where
- Madrid, SpainSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 12 and 21 years old?
Source: NCT07302802, who can take part
Where in Spain
- Departments of Pediatrics & Pediatric Endocrinology, Hospital Infantil Universitario Niño Jesús, Universidad Autónoma de MadridMadrid, SpainNot yet recruiting
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Prof. Dr. Martin Wabitsch
- Trial code
- NCT07302802
- Record updated
- 8 January 2026
- Original description
This observational study aims to assess the effect of once-weekly s.c. semaglutide 2.4 mg as an adjunct to a calorie-reduced diet and increased physical activity on weight loss, change in hunger, body composition, depression, and quality of life after 68 weeks of treatment in adolescents diagnosed with monogenic obesity in routine clinical care.Read full original descriptionShow less
This observational study aims to assess the effect of once-weekly s.c. semaglutide 2.4 mg as an adjunct to a calorie-reduced diet and increased physical activity on weight loss, change in hunger, body composition, depression, and quality of life after 68 weeks of treatment in adolescents diagnosed with monogenic obesity in routine clinical care.
Inclusion: Treatment with semaglutide as prescribed in routine clinical practice according to summary of product characteristics; Informed consent of the patient, their parents, or legally acceptable representative (LAR) of participant and adolescent assent, as age-appropriate; Age at time of signing informed consent: ≥12 to <21 years; BMI ≥95th percentile as defined on sex- and age-specific BMI growth charts (CDC.gov); Body weight of >60 kg; Diagnosis of monogenic obesity by a Clinical Laboratory Improvement Amendments (CLIA)/ College of American Pathologists (CAP)/International Organisation for Standardization (ISO) 1518-certified laboratory using ACMG criteria as pathogenic (P), likely pathogenic (LP) and variant of uncertain significance (VUS).
Exclusion: The safety and efficacy of Wegovy have not been investigated in patients:; treated with other products for weight management,; with type 1 diabetes,; with severe renal impairment (see section 4.2),; with severe hepatic impairment (see section 4.2),; with congestive heart failure New York Heart Association (NYHA) class IV. Use in these patients is not recommended; Hypersensitivity to the active substance or to any of the excipients listed:; Disodium phosphate, dihydrate; Propylene glycol; Phenol; Hydrochloric acid (for pH adjustment); Sodium hydroxide (for pH adjustment); Water for injection; Participation in any interventional clinical trials at the time of enrolment; Females of childbearing potential who are not using adequate contraceptive methods (as required by local law or practice).