Mirabegron in People With Dry Macular Degeneration and Overactive Bladder
Compares mirabegron with solifenacin for eye changes in dry macular degeneration.
Plain-language title generated from the registry record
Registry title: Mirabegron in Patients With Age-Related Macular Degeneration
Key facts
- Where
- Naples, ItalySee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 50 and 80 years old?
Source: NCT07305298, who can take part
Where in Italy
- Federico IINaples, ItalyNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of Naples
- Trial code
- NCT07305298
- Record updated
- 6 February 2026
- Original description
The goal of this clinical trial is to learn if Mirabegron works to treat dry AMD in patients, aged between 50 and 80 years-old, with early or moderate dry AMD and overactive bladder.Read full original descriptionShow less
Mirabegron in Patients With Age-Related Macular Degeneration Treated for Overactive Bladder: A Study Protocol for a Non-Randomized Prospective Controlled Trial
The goal of this clinical trial is to learn if Mirabegron works to treat dry AMD in patients, aged between 50 and 80 years-old, with early or moderate dry AMD and overactive bladder.
The main question it aims to answer is:
• Is there any change in outer retina morphology in patients treated?
Researchers will compare the safety and efficacy of mirabegron versus conventional approach (Solifenacin) to treat dry AMD in patients with dry AMD and overactive bladder.
Participants will:
* Take Mirabegron or Solifenacin every day for 12 months * Visit the clinic once every 6 months for checkups and tests
Inclusion: Age subjects 50 and 80 years-old; Ability to express informed consent; Early or moderate dry AMD according to ARDS classification; Overreactive bladder; Visual acuity greater than BCVA 65 EDTRS letters.
Exclusion: • Any medical condition which contraindicates the use of beta-agonists; Uncontrolled hypertension; Tachycardia or atrial fibrillation; Any allergies to the beta-agonists; Renal or hepatic failure; Long QT or concomitant treatment with drugs that cause lengthening of the QT interval; Any sign of ocular inflammation; xudative AMD; Any ongoing medical or surgical treatment for AMD (including intravitreal injections, oral supplementation of lutein, zeaxanthin and or high dietary intake of antioxidants); Any other ophthalmic diseases such glaucoma, acute or chronic uveitis, advanced cataract, or any opacities of the ocular media that do not permit high-quality imaging examinations; Pregnancy; Any condition or disease that in the opinion of the investigators may put the subject at significant risk or may interfere significantly with the subject's participation in the study (i. e. malignancy, uncontrolled or cardiovascular diseases).