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Stimulating the Piriform Cortex to Study Brain Networks in Drug-Resistant Epilepsy

Tests brain stimulation of the piriform cortex in people with drug-resistant epilepsy.

Plain-language title generated from the registry record
Registry title: Characterising the Network-Specific Effects of Piriform Cortex Stimulation Via SEEG

Key facts

Where
Beijing, ChinaSee the site

Could this be for you?

Answer for yourself. This is not a decision: only the study team can say whether you can take part.

  • Are you between 14 and 65 years old?

Source: NCT07305311, who can take part

Where in China

  • Xuanwu HospitalBeijing, ChinaNo longer taking part

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?
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Trial details

Who runs it
Xuanwu Hospital, Beijing
Trial code
NCT07305311
Record updated
26 December 2025
Original description
The prospective study aims to characterize the network-specific modulatory effects of piriform cortex stimulation in patients undergoing stereotactic EEG for drug-resistant epilepsy. Using multimodal data, it seeks to link stimulation-evoked electrophysiological responses across brain networks with clinical outcomes, to inform targeted neuromodulation therapies.Read full original descriptionShow less

Characterising the Network-Specific Effects of Piriform Cortex Stimulation Via SEEG With Multimodal Data Integration

The prospective study aims to characterize the network-specific modulatory effects of piriform cortex stimulation in patients undergoing stereotactic EEG for drug-resistant epilepsy. Using multimodal data, it seeks to link stimulation-evoked electrophysiological responses across brain networks with clinical outcomes, to inform targeted neuromodulation therapies.

Inclusion: The patients were diagnosed with drug-resistant epilepsy; The patients underwent stereoelectroencephalography (SEEG) implantation for pre-surgical evaluation of epilepsy, with at least one electrode target reaching the piriform cortex; Participants/parents/legal guardian provide informed consent for inclusion.

Exclusion: Subjects that experience surgical complications during the implant procedure will be excluded from the study.

ClinicalTrials.gov NCT07305311