Tests hydrogen water mouth care after oral cancer surgery with free flap reconstruction
Tests hydrogen water mouth care in adults with oral cancer recovering from flap surgery.
Plain-language title generated from the registry record
Registry title: Effectiveness of Hydrogen Water Intervention on Acute Oral Inflammation, Oral Microbiota, and Pain Following Free Flap Reconstruction in Patients With Oral Cancer
Key facts
- Where
- Kaohsiung City, TaiwanSee the site
Where in Taiwan
- Kaohsiung Medical University Chung-Ho Memorial HospitalKaohsiung City, TaiwanTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Kaohsiung Medical University Chung-Ho Memorial Hospital
- Trial code
- NCT07306546
- Record updated
- 27 October 2026
- Original description
This randomized, double-blind, parallel-group controlled trial evaluates the effectiveness of hydrogen water oral care on acute oral inflammation, oral microbiota, and pain in patients with oral cancer who have undergone free flap reconstruction. After postoperative transfer from the intensive care unit to the plastic surgery ward, eligible patients who provide written informed consent are randomly assigned in a 1:1 ratio to receive oral care with either hydrogen water or boiled drinking water for 7 days. Saliva samples and pain assessments are collected at baseline (T0), Day 3 (T1), and Day 7 (T2) of the intervention.Read full original descriptionShow less
Effectiveness of Hydrogen Water Intervention on Acute Oral Inflammation, Oral Microbiota, and Pain Following Free Flap Reconstruction in Patients With Oral Cancer
This randomized, double-blind, parallel-group controlled trial evaluates the effectiveness of hydrogen water oral care on acute oral inflammation, oral microbiota, and pain in patients with oral cancer who have undergone free flap reconstruction. After postoperative transfer from the intensive care unit to the plastic surgery ward, eligible patients who provide written informed consent are randomly assigned in a 1:1 ratio to receive oral care with either hydrogen water or boiled drinking water for 7 days. Saliva samples and pain assessments are collected at baseline (T0), Day 3 (T1), and Day 7 (T2) of the intervention.
Inclusion: Diagnosed with oral cancer and undergoing microsurgical flap reconstruction; Age 18 years or older; Clear consciousness; Able to communicate without difficulty in Mandarin, Taiwanese, or in writing.
Exclusion: Use of antibacterial mouthwash after surgery; Abnormal salivary secretion function or severe xerostomia.