Functional Hip Strength Improvement in Knee Osteoarthritis Following Single-Dose PRP and a 6-Week Home Exercise Program
Key facts
- Who runs it
- Firat University
- Where
- Türkiye1 site in 1 countryChoose a country to see its sites
- Trial code
- Status
- Completed
- People taking part
- 27 people enrolled
- Started
- 8 Jul 2025
- Ended
- 13 Dec 2025
- Type of study
- Interventional
- Treatments tested
- Platelet-Rich Plasma (PRP) Injection
- Home Exercise Program
- Record updated
- 29 December 2025
Who can take part
- Age
- 45 years to 70 years
- Sex
- Women only
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
Show all 9 criteriaShow less
Who can take part
- Female patients aged 45-70 years
- Radiographic knee osteoarthritis: Kellgren-Lawrence grade II-III in the affected knee and grade II or less in the unaffected knee
- Unilateral knee pain during activity with VAS score ≥5 (for at least the past 3 months)
- Referred to physiotherapy following a unilateral single-dose PRP injection
Who cannot take part
- History of lower-extremity surgery
- History of neurological, rheumatological and/or cognitive diseases
- Any intra-articular knee injection within the past 6 months
- Regular lower-extremity strengthening exercise or non-pharmacological treatment for knee OA within the past 6 weeks
- Unable to use a telephone
This trial has no sites in United States.
It has sites in one country. Choose a country to see its sites.
About the trial
What the trial wants to find out
This single-group longitudinal study evaluated changes in hip stability isometric strength, knee muscle strength, and activity-related pain in women with knee osteoarthritis following a single-dose intra-articular platelet-rich plasma (PRP) injection and a 6-week home exercise program. Outcomes were assessed at baseline (5 days post-injection), week 6, and week 12. The intervention included strengthening exercises for knee and hip muscle groups performed three times per week and regular walking encouragement with weekly phone follow-up for adherence.
The group in the trial
- Single Group: PRP Injection + Home Exercise ProgramTreatment being tested
All participants received a unilateral single-dose intra-articular platelet-rich plasma (PRP) injection for symptomatic knee osteoarthritis, followed by a 6-week home-based strengthening and functional exercise program performed 3 times per week. The exercise program targeted knee extensors/flexors and hip extensors/abductors/external rotators. Participants were encouraged to walk at least 30 minutes on at least 5 days per week and were contacted weekly by phone to support adherence.
Treatment: Platelet-Rich Plasma (PRP) Injection and Home Exercise Program
Data and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Functional Hip Strength and Pain Changes in Women With Knee Osteoarthritis Following a Single-Dose Intra-Articular Platelet-Rich Plasma Injection and a 6-Week Home Exercise Program: A Single-Group Longitudinal Study
- Record updated
- 29 December 2025