Comparing Lymph Node Removal Amounts During Prostate Cancer Surgery
Compares limited and extended lymph node removal alongside prostate surgery in men with prostate cancer.
Plain-language title generated from the registry record
Registry title: Limited Versus Extended Lymph Node Dissection During Radical Prostatectomy in Patients With Localized or Locally Advanced Prostate Cancer
Key facts
- Where
- Lyasny, BelarusSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for men with prostate cancer that has not spread to other organs and can be removed by surgery. It compares removing fewer lymph nodes with removing more lymph nodes during prostate removal surgery.
- Age
- Over 18 years
- Sex
- Men only
- Disease stage
- Prostate cancer confirmed by biopsy, limited to the prostate area or growing into nearby tissue (adenocarcinoma without a neuroendocrine component), with no signs of spread to other parts of the body. The tumour must be removable by surgery.
- Earlier treatment
- People who had radiation therapy to the pelvis cannot join.
Main reasons for not taking part
- Another active invasive cancer
- A reason that rules out removing pelvic lymph nodes, such as earlier radiation to the pelvis
- Signs of cancer in the nearby lymph nodes on tests before surgery, including PET/CT with PSMA
- A severe other illness that limits taking part in the study
Read by machine on 9 November 2026.
Where in Belarus
- N.N. Alexandrov National Cancer CentreLyasny, BelarusTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- N.N. Alexandrov National Cancer Centre
- Trial code
- NCT07308990
- Record updated
- 30 December 2025
- Original description
This is a randomized controlled study assessing outcome of low (no or limited) versus high (limited or extended) extent of lymph node dissection in addition to radical prostatectomy in patients with operable localized or locally advanced prostate cancer.Read full original descriptionShow less
To Develop and Implement a Method for Optimizing the Volume of Lymph Node Dissection in Radical Surgical Treatment of Localized or Locally Advanced Prostate Cancer
This is a randomized controlled study assessing outcome of low (no or limited) versus high (limited or extended) extent of lymph node dissection in addition to radical prostatectomy in patients with operable localized or locally advanced prostate cancer.
Inclusion: Age over 18 years; Histologically confirmed localized or locally advanced prostate cancer (adenocarcinoma without a neuroendocrine component); No evidence of metastatic spread of the tumor; Local resectability of the tumor according to digital rectal examination and/or CT and/or MRI of the pelvis; Patients are suitable for radical prostatectomy based on their comorbidities and life expectancy; Signed informed consent to participate in the study.
Exclusion: Severe concomitant disease limiting participation in the study; Presence of another active malignant invasive neoplasm; Contraindication to pelvic lymph node dissection (e.g., history of radiation therapy to the pelvis); The evidence of metastases in regional lymph nodes according to preoperative examination data (including PET/CT with PSMA).