Using an MRI blood pressure measure to assess stroke risk in narrowed brain arteries
Studies whether an MRI pressure measure relates to stroke risk in intracranial atherosclerosis.
Plain-language title generated from the registry record
Registry title: MPR for Stroke Risk Assessment of ICAS
Key facts
- Where
- Beijing, ChinaSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 80 years old?
Source: NCT07309718, who can take part
Where in China
- Department of Neurosurgery, Xuanwu hospitalBeijing, ChinaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Xuanwu Hospital, Beijing
- Trial code
- NCT07309718
- Record updated
- 30 December 2025
- Original description
Intracranial atherosclerotic stenosis (ICAS) carries substantial stroke risk despite optimal medical treatment. Current risk stratification relies primarily on stenosis severity, but novel hemodynamic markers may improve prediction. In this multiple prospective registry study we aim to investigate whether regional hemodynamics, measured by a novel Magnetic resonance imaging-derived Pressure Ratio (MPR) technique, are associated with stroke risk in ICAS.Read full original descriptionShow less
MRI-Derived Pressure Ratio: a Novel Noninvasive Hemodynamic Biomarker for Stroke Risk Stratification in Intracranial Atherosclerotic Stenosis
Intracranial atherosclerotic stenosis (ICAS) carries substantial stroke risk despite optimal medical treatment. Current risk stratification relies primarily on stenosis severity, but novel hemodynamic markers may improve prediction. In this multiple prospective registry study we aim to investigate whether regional hemodynamics, measured by a novel Magnetic resonance imaging-derived Pressure Ratio (MPR) technique, are associated with stroke risk in ICAS.
Inclusion: Adults aged 18 to 80 years; Intracranial atherosclerotic stenosis ICAS involving a culprit artery in the anterior circulation; Intracranial arterial stenosis of 50% to 99% as measured by the WASID method using TCD, CTA, MRA, or DSA; Written informed consent obtained from the participant or a legal representative.
Exclusion: Contraindications to antiplatelet therapy or statins; Inability to undergo MRI due to metal implants or claustrophobia; Non-atherosclerotic intracranial lesions, including moyamoya disease, vasculitis, vascular dissection, autoimmune diseases, or congenital/genetic abnormalities; More than 50% stenosis of the extracranial carotid artery on the ipsilateral side; Large cerebral infarction involving more than one-half of the territory on DWI imaging, or a baseline modified Rankin Scale score ≥3.