Links between low oxygen during sleep apnea and small heart vessel problems
Studies how low oxygen at night relates to heart vessel problems in adults.
Plain-language title generated from the registry record
Registry title: The Correlation Between Obstructive Sleep Apnea-Related Nocturnal Hypoxemia Parameters and Coronary Microvascular Dysfunction: A Prospective Cohort Study (SLEEP-CMD)
Key facts
- Where
- Beijing, ChinaSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults aged 18 to 80 who are scheduled for planned coronary angiography because of symptoms or signs of reduced blood flow to the heart, and who can complete an overnight sleep study.
- Age
- 18 to 80 years
- Sex
- All sexes can join.
- Disease stage
- Symptoms or evidence of myocardial ischemia (reduced blood flow to the heart muscle), with elective coronary angiography planned.
Main reasons for not taking part
- Coronary chronic total occlusion, bypass surgery in the past, severe heart valve disease, cardiomyopathy, congenital heart disease, or heart failure (NYHA class III-IV)
- Sleep-disordered breathing that is mainly central sleep apnea
- Severe liver failure (Child-Pugh class C) or kidney failure (eGFR < 30 mL/min/1.73 m²)
- Pregnancy or breastfeeding
- Life expectancy of less than 2 years
Read by machine on 13 November 2026.
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 80 years old?
Source: NCT07315399, who can take part
Where in China
- Beijing Anzhen Hospital, Capital Medical UniversityBeijing, ChinaContact: Chenchen Tu, DoctorNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Beijing Anzhen Hospital
- Trial code
- NCT07315399
- Record updated
- 2 January 2026
- Original description
In a cohort of patients with suspected myocardial ischemia undergoing sleep studies, the objectives of this study were:Read full original descriptionShow less
The Correlation Between Obstructive Sleep Apnea-Related Nocturnal Hypoxemia Parameters and Coronary Microvascular Dysfunction: A Prospective Cohort Study
In a cohort of patients with suspected myocardial ischemia undergoing sleep studies, the objectives of this study were:
1. To determine the association between various obstructive sleep apnea (OSA)-related nocturnal hypoxemia parameters and coronary microvascular dysfunction (CMD) in patients with suspected myocardial ischemia. 2. To compare the predictive value of nocturnal hypoxemia parameters versus the traditional Apnea-Hypopnea Index (AHI) for coronary microvascular dysfunction. 3. To evaluate the prognostic value of nocturnal hypoxemia parameters in predicting Major Adverse Cardiovascular Events (MACE) during the follow-up period. 4. To explore the potential mediating roles of inflammatory and oxidative stress biomarkers in the relationship between nocturnal hypoxemia parameters and coronary microvascular dysfunction.
Inclusion: Aged 18 to 80 years, of any gender; Scheduled for elective coronary angiography due to symptoms or evidence of myocardial ischemia; Agreed to and capable of completing overnight polysomnography (PSG) monitoring; Provided written informed consent and were willing and able to comply with baseline assessments and long-term follow-up.
Exclusion: Presence of coronary chronic total occlusion (CTO), history of coronary artery bypass grafting (CABG), severe valvular heart disease, dilated or hypertrophic cardiomyopathy, congenital heart disease, or heart failure (NYHA functional class III-IV); Life expectancy of less than 2 years, or any other condition that the investigators considered unsuitable for participation in the study; Severe hepatic insufficiency (Child-Pugh class C) or renal failure (eGFR < 30 mL/min/1.73 m²); Sleep-disordered breathing with central sleep apnea (CSA) as the primary manifestation; Pregnancy or lactation.