Exercise and glucose tracking program for knee arthritis and obesity
Tests a community exercise program with glucose monitoring in adults with knee arthritis and obesity.
Plain-language title generated from the registry record
Registry title: The NTU JO-SMART Study
Key facts
- Where
- Taipei and Yunlin, TaiwanSee the 2 sites
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 75 years old?
Source: NCT07317310, who can take part
Where in Taiwan
- National Taiwan University HospitalTaipei, TaiwanTaking people
- National Taiwan University Hospital Yunlin BranchYunlin, TaiwanTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- National Taiwan University Hospital
- Trial code
- NCT07317310
- Record updated
- 24 July 2026
- Original description
This study recruits patients with coexisting obesity and knee osteoarthritis (KOA) to implement the NTU-JO Smart Program, an innovative intervention integrating AI-assisted community-based exercise with continuous glucose monitoring (CGM). The primary objective is to investigate whether this intervention can improve glycemic control in this comorbid population. Other outcome measures include the risk of total knee arthroplasty (TKA), body weight changes, pain intensity scores, bone mineral density (BMD), cognitive function, as well as the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and Patient-Reported Outcomes Measurement Information System (PROMIS) scores, which reflect the patients' overall functional status. The project also sought to explore the long-term association of the NTU-JO Smart Program with the development of type 2 diabetes (T2D) and major renal events, thereby facilitating patient-centered early treatment.Read full original descriptionShow less
Effects of the NTU-JO Smart Program for People With Knee Osteoarthritis and Obesity: a Multicenter Pragmatic Randomized Controlled Trial
This study recruits patients with coexisting obesity and knee osteoarthritis (KOA) to implement the NTU-JO Smart Program, an innovative intervention integrating AI-assisted community-based exercise with continuous glucose monitoring (CGM). The primary objective is to investigate whether this intervention can improve glycemic control in this comorbid population. Other outcome measures include the risk of total knee arthroplasty (TKA), body weight changes, pain intensity scores, bone mineral density (BMD), cognitive function, as well as the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and Patient-Reported Outcomes Measurement Information System (PROMIS) scores, which reflect the patients' overall functional status. The project also sought to explore the long-term association of the NTU-JO Smart Program with the development of type 2 diabetes (T2D) and major renal events, thereby facilitating patient-centered early treatment.
Inclusion: Age: 18 to 75 years; Obesity status: body mass index (BMI) ≥ 27 kg/m², consistent with the obesity definition defined by the Health Promotion Administration, Ministry of Health and Welfare, Taiwan; Diagnosis of KOA in at least one knee according to the American College of Rheumatology (ACR) criteria, with a Kellgren-Lawrence (KL) grade of 1, 2, or 3; Symptomatic disease: defined as a WOMAC pain subscale score (range 0-20) greater than 4 at screening; Sedentary lifestyle: defined as less than 30 minutes of physical activity per week for the past 6 months; Informed consent: willing and able to provide written informed consent and comply with all longitudinal study procedures; Comorbid status: participants may be included regardless of a baseline diagnosis of T2D or CKD. Stratified randomization and subgroup analyses will be conducted based on these baseline conditions.
Exclusion: Knee arthroscopy within the past 3 months or previous surgical history of TKA; Recent receipt of intra-articular injections (e.g., corticosteroids, hyaluronic acid) within the past 3 months; Engagement in dietary regimens likely to cause significant weight change (e.g., intermittent fasting, such as the 16:8 time-restricted eating) within 1 month prior to trial initiation; Use of any FDA-approved weight-loss medications (e.g., semaglutide, tirzepatide) within 3 months prior to trial initiation; Documented history of osteoporotic fracture in hospital or cloud-based medical records; Type 1 diabetes; Presence of conditions precluding safe participation in an exercise program, such as unstable cardiovascular disease or severe neurological disorders; History of any form of surgical treatment for weight loss; Current malignancy (within the validity period of a catastrophic illness certificate), or any other clinical condition deemed unsuitable for participation by the investigator (investigator discretion); Inability to use smart devices or telecommunication tools due to severe visual/hearing impairment or lack of internet access; KL grade 4 KOA in either knee; Diagnosis of inflammatory arthritis, such as rheumatoid arthritis or psoriatic arthritis; Participation in another interventional clinical trial within the past 3 months; Current use of lithium or antipsychotics at a dose equivalent to olanzapine >20 mg/day; Pregnant or breastfeeding women, or women of childbearing potential without adequate contraception.