Tests fewer follow-up colonoscopies after removal of large bowel polyps
Compares relaxed and standard colonoscopy schedules in adults after large bowel polyp removal.
Plain-language title generated from the registry record
Registry title: Delayed Surveillance Colonoscopy Following Piecemeal EMR
Key facts
- Where
- Haifa, IsraelSee the site
Where in Israel
- Rambam Medical CenterHaifa, IsraelNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Rambam Health Care Campus
- Trial code
- NCT07328308
- Record updated
- 9 January 2026
- Original description
This multicenter, prospective, randomized non inferiority trial, conducted at four Israeli hospitals, will evaluate whether a relaxed surveillance strategy after piecemeal endoscopic mucosal resection (pEMR) of large non pedunculated colorectal polyps (LNPCPs, ≥20 mm) is as safe and effective as the current standard intensive surveillance. Approximately 760 adults undergoing complete pEMR with margin ablation will be randomized 1:1 into:Read full original descriptionShow less
Delayed Surveillance Colonoscopy Following Piecemeal EMR - a Randomized Study
This multicenter, prospective, randomized non inferiority trial, conducted at four Israeli hospitals, will evaluate whether a relaxed surveillance strategy after piecemeal endoscopic mucosal resection (pEMR) of large non pedunculated colorectal polyps (LNPCPs, ≥20 mm) is as safe and effective as the current standard intensive surveillance. Approximately 760 adults undergoing complete pEMR with margin ablation will be randomized 1:1 into:
Standard Surveillance: Colonoscopy at 6, 18, and 48 months
Relaxed Surveillance: Colonoscopy at 12 and 48 months
All colonoscopies will be performed using high definition white light and narrow band imaging, with biopsies obtained only if recurrence is suspected. The investigators hypothesize that a relaxed surveillance strategy will be non inferior to the current standard intensive surveillance. If non inferiority is demonstrated, the study may support guideline changes toward reduced surveillance frequency after pEMR with margin ablation, potentially decreasing patient burden and healthcare costs.
Inclusion: Adults aged 18 years and older; Undergoing pEMR of LNPCPs; Able to provide informed consent and comply with follow-up requirements.
Exclusion: en bloc resection; Patients who require additional surgery for polyp removal or other complications; Patients with invasive cancer identified during the index procedure; Patients unable to attend follow-up colonoscopies due to comorbid conditions.