Neck Lymph Vessel Surgery for Problems With Lymph Flow Around the Brain
Tests connecting neck lymph vessels and nodes to veins in people with lymph flow disorder.
Plain-language title generated from the registry record
Registry title: Effect of Cervical Lymphaticovenous and Lymph Node-to-Vein Anastomosis in Patients With Intracranial Lymphatic Circulation Disorder
Key facts
- Where
- Seoul, South KoreaSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 19 and 100 years old?
Source: NCT07328386, who can take part
Where in South Korea
- Asan Medical CenterSeoul, South KoreaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Hong Joonpio
- Trial code
- NCT07328386
- Record updated
- 9 January 2026
- Original description
This study is a single-center, prospective clinical trial designed to evaluate the therapeutic effects of lymphaticovenular anastomosis (LVA) and lymph node-venous anastomosis (LNVA) in patients with intracranial lymphatic circulation disorders. Following voluntary written informed consent, screening assessments will be performed in accordance with the clinical trial protocol. Eligibility will be determined based on the predefined inclusion and exclusion criteria, and eligible subjects will be enrolled in the study. Enrolled participants will undergo cognitive function assessments at baseline (pre-surgery) and at 1, 3, 6, 9, 12, 18, and 24 months postoperatively for follow-up. Cognitive evaluations will not be additionally performed for research purposes but will be conducted in accordance with the existing clinical care schedule and standard treatment guidelines.Read full original descriptionShow less
Effect of Cervical Lymphaticovenous Anastomosis and Cervical Lymph Node to Vein Anastomosis for the Patient With Intracranial Lymphatic Circulation Disorder
This study is a single-center, prospective clinical trial designed to evaluate the therapeutic effects of lymphaticovenular anastomosis (LVA) and lymph node-venous anastomosis (LNVA) in patients with intracranial lymphatic circulation disorders. Following voluntary written informed consent, screening assessments will be performed in accordance with the clinical trial protocol. Eligibility will be determined based on the predefined inclusion and exclusion criteria, and eligible subjects will be enrolled in the study. Enrolled participants will undergo cognitive function assessments at baseline (pre-surgery) and at 1, 3, 6, 9, 12, 18, and 24 months postoperatively for follow-up. Cognitive evaluations will not be additionally performed for research purposes but will be conducted in accordance with the existing clinical care schedule and standard treatment guidelines.
Inclusion: Patients aged 19 years or older who are diagnosed with intracranial lymphatic circulation disorder based on neurological evaluation; Global Deterioration Scale (GDS) score between 3 and 5 at screening; Diagnosis of Alzheimer's disease confirmed by amyloid PET-CT or CSF amyloid testing, showing amyloid accumulation associated with lymphatic circulation disorder; Able to provide written informed consent to participate in the study voluntarily.
Exclusion: Unable to undergo follow-up evaluation for at least 12 months after surgery; History of previous neck surgery; Diagnosed with vascular dementia; Presence of structural brain disease other than intracranial lymphatic circulation disorder; Known hypersensitivity to indocyanine green (ICG); Uncontrolled systemic medical conditions such as severe cardiopulmonary, renal, hepatic, or endocrine disorders; Refusal to participate or failure to provide informed consent; Determined by the principal investigator to be unsuitable for participation due to any other clinical reason.