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Femoral Nerve Mobilization for Patients With Knee Osteoarthritis

Key facts

Who runs it
Prince Sattam Bin Abdulaziz University
Where
Saudi Arabia1 site in 1 countryChoose a country to see its sites
Trial code
Status
Not yet recruiting
People taking part
50 people, planned
Started
20 Dec 2025
Planned end
25 Feb 2026
Type of study
Interventional, 2 groupsOne group gets an existing treatment, for comparison.
Treatments tested
  • traditional physical therapy
  • Femoral nerve mobilization
Record updated
9 January 2026

Who can take part

Age
50 years and older
Sex
Women and men
Healthy volunteers
Cannot take part

The registry criteria, word for word

Show all 8 criteriaShow less

Who can take part

  • patients aged 50 years or older, diagnosed with KO according to theAmerican College of Rheumatology's criteria with knee pain, and grade I or II on the Kellgren-Lawrence radiographic scale

Who cannot take part

  • those who had undergone corticosteroid or local anesthetic infiltration in the year prior to the study or during the follow-up period
  • those with a previous diagnosis of neuropathy (lumbosacral plexus) or myopathy
  • individuals suffering from chronic conditions considered to be perpetuating factors (e.g., fibromyalgia)
  • those with conditions causing lower extremity pain
  • those with contraindications to mobilization or exercise, and those with cognitive deficits (dementia, Alzheimer's)
  • individuals who had taken analgesics within 24 h before evaluations
  • those using substances that could interfere with treatment

This trial has no sites in United States.

It has sites in one country. Choose a country to see its sites.

About the trial

What the trial wants to find out

Background: Knee osteoarthritis (KO) is considered as a cause of disability among the elderly, causing pain, reduced quality of life, and decreased functionality. There is a limited knowledge about using femoral nerve mobilization in treating patients with arthritic changes.

Read full original descriptionShow less

Objectives: This study will be designed to determine the efficacy of adding of femoral nerve mobilization on pain intensity, function, quality of life and central sensitization in patients with knee osteoarthritis Methods: Thirty patients (aged ≥50 years with KO Kellgren-Lawrence grades I-II) will be included in this study: Patients will randomly be assigned into two groups: group A will receive traditional physical therapy while group B will receive femoral nerve mobilization in addition to traditional physical therapy. Three sessions will be performed for four weeks by 3 session /week. Patients will be evaluated for pain intensity using the numerical rating scale (NRS), knee function by WOMAC scale, quality of life by 12-item Short Form Survey questionnaire (SF-12) and central sensitization by the Arabic version of central sensitization inventory (CSI).

The 2 groups in the trial

  • Control groupExisting treatment, for comparison

    Traditional physical therapy

    Treatment: traditional physical therapy

  • Neural mobilization groupTreatment being tested

    traditional physical therapy plus femoral nerve mobilization

    Treatment: traditional physical therapy and Femoral nerve mobilization

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

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Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
Effects of Femoral Nerve Mobilization on Pain Intensity, Function, Quality of Life and Central Sensitization in Patients With Knee Osteoarthritis
Record updated
9 January 2026