AI scan versus pressure wire to guide stent treatment in heart disease
Tests an AI-based scan against a pressure wire to guide stents in heart artery disease.
Plain-language title generated from the registry record
Registry title: Artificial Intelligence-Driven Medipixel Fractional Flow Reserve Versus Invasive Fractional Flow Reserve-Guided PCI Trial (AIM-FFR Trial)
Key facts
- Where
- Busan, Changwon, Daegu, Gwangju, Gwangmyeong, Gyeonggi-do, Iksan, Ilsan, Incheon, Jinju, Seongnam, Seoul, Suwon, Uijeongbu-si, Ulsan, and Wŏnju, South KoreaSee the 23 sites
Where in South Korea
- Inje University Haeundae Paik HospitalBusan, South KoreaTaking people
- Changwon Fatima HospitalChangwon, South KoreaTaking people
- Gyeongsang National University Changwon hospitalChangwon, South KoreaTaking people
- Keimyung University Dongsan HospitalDaegu, South KoreaTaking people
- Kyungpook National University HospitalDaegu, South KoreaTaking people
- Chonnam National University Hospital, Chonnam National University Medical SchoolGwangju, South KoreaTaking people
- Chung-Ang University Gwangmyeong HospitalGwangmyeong, South KoreaTaking people
- CHA Bundang Medical CenterGyeonggi-do, South KoreaTaking people
- Wonkwang University HospitalIksan, South KoreaTaking people
- Inje University College of Medicine, Ilsan Paik HospitalIlsan, South KoreaTaking people
- Gachon University Gil Medical CenterIncheon, South KoreaTaking people
- International St. Mary's HospitalIncheon, South KoreaTaking people
- Gyeongsang National University HospitalJinju, South KoreaTaking people
- Seoul National University Bundang HospitalSeongnam, South KoreaTaking people
- Kangbuk Samsung Hospital, Sungkyunkwan University School of MedicineSeoul, South KoreaTaking people
- Korea University Anam HospitalSeoul, South KoreaTaking people
- Korea University Guro HospitalSeoul, South KoreaTaking people
- Samsung Medical CenterSeoul, South KoreaTaking people
- Seoul National University Boramae Medical CenterSeoul, South KoreaTaking people
- Ajou University HospitalSuwon, South KoreaTaking people
- Uijeongbu ST. Mary's HospitalUijeongbu-si, South KoreaTaking people
- Ulsan University HospitalUlsan, South KoreaTaking people
- Wonju Severance Christian HospitalWŏnju, South KoreaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Samsung Medical Center
- Trial code
- NCT07329699
- Record updated
- 23 April 2026
- Original description
The AIM-FFR trial is a prospective, multi-center, open-label, randomized controlled, non-inferiority trial. The current trial will evaluate non-inferiority of MPFFR-guided PCI, compared with invasive FFR-guided PCI in patients with coronary artery disease.Read full original descriptionShow less
Artificial Intelligence-Driven Angiography-Based Fractional Flow Reserve Versus Invasive Fractional Flow Reserve-Guided PCI
The AIM-FFR trial is a prospective, multi-center, open-label, randomized controlled, non-inferiority trial. The current trial will evaluate non-inferiority of MPFFR-guided PCI, compared with invasive FFR-guided PCI in patients with coronary artery disease.
Inclusion: Subject must be at least 19 years of age; Eligible for coronary angiography and/or percutaneous coronary intervention; Chronic coronary syndrome or acute coronary syndrome (non-culprit vessels only); Coronary artery disease in one or more native major epicardial vessels or their branches with reference vessel diameter of at least 2.5mm and with visually assessed coronary stenosis in which the physiological severity of the lesion is questionable (typically 40-90% diameter stenosis); Subject who is able to understand risks, benefits and treatment alternatives and sign informed consent voluntarily.
Exclusion: Patients with known intolerance to aspirin, P2Y12 inhibitors, or components of drug-eluting stents and drug-coated balloons; Patients who have non-cardiac co-morbid conditions with life expectancy <1 year; Patients with cardiogenic shock or cardiac arrest; Patients with severe valvular heart disease requiring open heart surgery; Angiographic exclusion criteria; Culprit vessel of patients with ST-elevation myocardial infarction (target lesions in non-culprit vessel can be enrolled); Chronic total occlusion (target lesions in vessels without chronic total occlusion can be enrolled); Ostial stenosis in left man coronary artery or right coronary artery; Severe tortuosity of any target vessel; Severe overlap in the stenosed segment; Poor image quality precluding identification of vessel contours; Patients with severe left ventricular systolic dysfunction (ejection fraction <30%); Patients unable to provide informed consent; Patients with coronary artery bypass grafting; Pregnant or lactating women.