Tests a team-supported plan to lower cholesterol in patients with heart artery disease
Tests a team-supported cholesterol plan in adults with atherosclerotic cardiovascular disease.
Key facts
- Who runs it
- Colorado Prevention Center
- Where
- Aurora, United StatesSee the site
- Trial code
- Registry title
- Implementation of an Algorithm- and Multi-professional Team-supported Strategy to Improve Lipid Management of Patients With Atherosclerotic Cardiovascular Disease
- Status
- Recruiting
- People taking part
- 100 people, planned
- Started
- 10 Dec 2025
- Expected to end
- Jul 2027
- Type of study
- Interventional, 2 groups
- Treatments tested
- Algorithm- and multi-professional team-supported lipid management
- Guideline-directed lipid management by usual care provider
- Record updated
- 23 January 2026
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with atherosclerotic cardiovascular disease (fatty build-up in the arteries) and LDL-cholesterol above 70mg/dL (1.8 mmol/L). It tests team-supported cholesterol care against usual care.
- Age
- Older than 18 years
- Sex
- All sexes can join.
- Disease stage
- Documented atherosclerotic vascular disease: coronary artery disease, peripheral artery disease, carotid artery disease, or imaging evidence of it in another artery such as the aorta, mesenteric or renal arteries.
- Earlier treatment
- People with a planned active change of their current cholesterol-lowering treatment cannot join.
- Biomarker or test result
- LDL-C above 70mg/dL (1.8 mmol/L).
Main reasons for not taking part
- Cannot follow the trial plan, for example terminal diagnosis or metastatic cancer
- Participation might cause harm
- Planned active change of current lipid-lowering therapy
- Heart attack or arterial revascularization in the last 30 days
The registry criteria, word for word
Show all 6 criteriaShow less
Who can take part
- Provided informed consent
- Age >18 years inclusive at screening
- Documented atherosclerotic vascular disease including:; Coronary artery disease (prior revascularization, myocardial infarction, imaging evidence of coronary atherosclerosis); Peripheral artery disease (prior revascularization, amputation, ankle: brachial index (ABI) ≤ 0.90, imaging evidence of extra-coronary atherosclerosis); Carotid artery disease (prior endarterectomy or stenting of the extracranial carotid artery or imaging evidence of carotid atherosclerosis); Imaging evidence of atherosclerotic vascular disease in a non-coronary vascular bed (e.g. aorta, mesenteric, renal); LDL-C >70mg/dL
Who cannot take part
- Planned active titration of current lipid-lowering therapy
- Myocardial infarction or arterial revascularization within prior 30 days
- Any reason that, in the opinion of the investigator, the patient would be unable to adhere to the protocol for the duration of the study (e.g. terminal diagnosis, metastatic cancer) or in whom participation might result in harm
Where in United States
- University of Colorado Health System (UCHealth)Aurora, United StatesContact: Marc Bonaca, MDTaking people
About the trial
What the trial wants to find out
This is a randomized, controlled, collaborative, multicenter, pilot implementation science study evaluating the hypothesis that algorithm- and multi-professional team-supported lipid management reduces low density lipoprotein-cholesterol (LDL-C) compared with usual care in patients with atherosclerotic cardiovascular disease (ASCVD).
The 2 groups in the trial
- Control: Guideline-directed lipid management by usual care providerOther group
Treatment: Guideline-directed lipid management by usual care provider
- Algorithm- and multi-professional team-supported lipid managementTreatment being tested
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Implementation of an Algorithm- and Multi-professional Team-supported Strategy to Improve Lipid Management of Patients With Atherosclerotic Cardiovascular Disease: OPTIMIZE ASCVD
- Plain-language title
- Tests a team-supported plan to lower cholesterol in patients with heart artery diseaseGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 13 November 2026.
- Record updated
- 23 January 2026